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Table 3 Odds ratios of postmenopausal breast cancer for BMI at age 20, age 50 and current age, and for BMI gain from age 20 to current age, age 20 to 40, age 40 to 50, and age 50 to current age par category and per increment of 5 kg/m2 of BMI or BMI gain

From: Weight and weight changes throughout life and postmenopausal breast cancer risk: a case-control study in France

  Cases Controls ORa 95 % CI p trendb
  (n = 739) (n = 815)
  N % N %    
BMI at age 20 (kg/m2)
  < 18.5 146 20.3 150 19.0 1.10 [0.84-1.44]  
  ≥ 18.5 < 25 527 73.2 587 74.2 1 ref  
  ≥ 25 47 6.5 54 6.8 0.92 [0.60-1.41]  
Per 5 kg/m 2    1.03 [0.85-1.25] 0.76
BMI at age 50 (kg/m2)
  < 18.5 34 4.9 29 3.8 1.14 [0.67-1.96]  
  ≥ 18.5 < 25 461 65.8 510 66.6 1 ref  
  ≥ 25 < 30 147 21.0 162 21.1 1.07 [0.81-1.40]  
  ≥ 30 59 8.4 65 8.5 1.05 [0.70-1.56]  
Per 5 kg/m 2    1.07 [0.94-1.22] 0.30
Current BMI (kg/m2)
  < 18.5 15 2.0 21 2.6 0.73 [0.36-1.50]  
  ≥ 18.5 < 25 374 50.7 407 50.0 1 ref  
  ≥ 25 < 30 223 30.3 245 30.1 1.03 [0.80-1.31]  
  ≥ 30 125 17.0 141 17.3 1.04 [0.77-1.41]  
Per 5 kg/m 2    1.03 [0.92-1.14] 0.62
BMI change from age 20 to current age (kg/m2)
  < 1 139 19.3 161 20.4 1 ref  
  ≥ 1 < 3 140 19.4 136 17.2 1.18 [0.83-1.66]  
  ≥ 3 < 6 196 27.2 211 26.7 1.10 [0.81-1.51]  
  ≥ 6 245 34.0 283 35.8 1.06 [0.78-1.44]  
Per 5 kg/m 2    1.02 [0.91-1.14] 0.76
BMI change from age 20 to 40 (kg/m2)
  < 1 306 44.0 338 43.8 1 ref  
  ≥ 1 < 3 240 34.5 232 30.1 1.22 [0.95-1.57]  
  ≥ 3 150 21.6 202 26.2 0.88 [0.66-1.16]  
Per 5 kg/m 2    0.88 [0.74-1.06] 0.18
BMI change from age 40 to 50 (kg/m2)
  < 1 329 48.2 396 52.7 1 ref  
  ≥ 1 < 3 223 32.7 234 31.2 1.18 [0.92-1.51]  
  ≥ 3 131 19.2 121 16.1 1.45 [1.06-1.98]  
Per 5 kg/m 2    1.32 [1.05-1.65] 0.02
BMI change from age 50 to current age (kg/m2)
  < 1 310 44.2 321 41.9 1 ref  
  ≥ 1 < 3 212 30.2 240 31.3 0.95 [0.73-1.23]  
  ≥ 3 179 25.5 205 26.8 0.97 [0.73-1.29]  
Per 5 kg/m 2    1.00 [0.83-1.21] 0.97
  1. aOdds ratio adjusted for study area, age at reference date, age at menarche, parity, age at first full-term pregnancy, breastfeeding, family history of breast cancer, oral contraceptive use, current use of MHT, alcohol consumption, tobacco smoking, and physical activity
  2. bp for trend calculated from the model using BMI or BMI change as continuous variables