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Fig. 3 | BMC Cancer

Fig. 3

From: Novel biomarkers that assist in accurate discrimination of squamous cell carcinoma from adenocarcinoma of the lung

Fig. 3

IHC for the novel marker candidates. A case of pure lepidic AD (a-d). H.E. staining (a) and IHC for TTF-1 (b), SPATS2 (c) and ST6GALNAC1 (d). The tumor cells are diffusely positive for ST6GALNAC1, but negative for TTF1 and SPATS2. A case of non-lepidic AD (e-h). H.E. staining (e) and IHC for TTF-1 (f), SPATS2 (g) and ST6GALNAC1 (h). The tumor cells are diffusely positive for ST6GALNAC1, but negative for TTF1 and SPATS2. Note that infiltrating plasma cells are also positive for SPATS2 (g). A case of WDSCC (i-l). H.E. staining (i) and IHC for p40 (j), SPATS2 (k) and ST6GALNAC1 (l). The tumor cells are diffusely positive for SPATS2 and p40, but negative for ST6GALNAC1. A case of PDSCC (m-p). H.E. staining (m) and IHC for p40 (n), SPATS2 (o) and ST6GALNAC1 (p). The tumor cells are diffusely positive for SPATS2, but negative for p40 and ST6GALNAC1. Note that SPATS2 staining is more sensitive than p40 staining. (original magnifications: x100, insets: x400)

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