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Table 4 Validation test of the five tumour suppressor genes as a panel

From: Salivary DNA methylation panel to diagnose HPV-positive and HPV-negative head and neck cancers

  Mean Bootstrap SD 2.50 % 97.50 % Pval
(a) Diagnostic potential of the panel for HPV-negative HNSCC
Sensitivity 0.67 0.14 0.38 0.94 0.16
Specificity 0.83 0.13 0.50 1.00 0.04
PPV 0.79 0.12 0.55 1.00 0.003
NPV 0.77 0.08 0.63 0.94 0
(b) Diagnostic potential of the panel for HPV-positive HNSCC
Sensitivity 0.76 0.17 0.33 1.00 0.15
Specificity 0.67 0.14 0.35 0.90 0.16
PPV 0.53 0.12 0.33 0.78 0.74
NPV 0.87 0.08 0.70 1.00 0
(c) Diagnostic potential of the panel for HNSCC irrespective of HPV status
Sensitivity 0.59 0.14 0.33 0.88 0.46
Specificity 0.78 0.15 0.45 1.00 0.07
PPV 0.78 0.10 0.59 1.00 0
NPV 0.62 0.08 0.50 0.8 0.04
  1. Four main quantities commonly assessed in a diagnostic test (namely; sensitivity, specificity and positive and negative predictive value) are calculated for this panel. The table was formulated into three grouping for three different comparisons: (a) HPV-negative HNSCC patients against normal healthy controls, (b) HPV-positive HNSCC patients against normal healthy controls and lastly (c) all HNSCC patients (regardless of HPV status) against normal healthy controls. The results shown are the mean, standard deviation, 95 % confidence interval and the p value (assessed from the null hypothesis value of 0.5) for 5000 bootstrap samples, using five-fold cross-validation