Skip to main content

Table 3 The clinical performance for the individual tumour suppressor genes

From: Salivary DNA methylation panel to diagnose HPV-positive and HPV-negative head and neck cancers

HPV-status Biomarker/Predictor Sensitivity (%) Specificity (%) PPV (%) NPV (%) AUC p-value
HPV-negative RASSF1a 41 92 66 80 0.69 <0.0001*
p16 INK4a 47 69 62 55 0.55 0.12
TIMP3 37 82 62 62 0.56 0.10
PCQAP 5 82 46 76 55 0.70 <0.0001*
PCQAP 3 34 85 62 64 0.59 <0.005*
HPV-positive RASSF1a 68 40 75 32 0.53 0.77
p16 INK4a 73 67 86 48 0.69 <0.005*
TIMP3 27 92 75 58 0.51 0.94
PCQAP 5 81 44 84 38 0.62 <0.05*
PCQAP 3 76 63 86 46 0.68 <0.005*
  1. The summary of predictive accuracy of the five individual DNA methylation genes in saliva collected from normal healthy controls and HPV-negative and HPV-positive HNSCC patients using Mann-Whitney’s U-test and receiver operative characteristic curve. Significant difference between each category was marked with *