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Table 1 The demographic characteristics of the study cohort (n = 255)

From: Salivary DNA methylation panel to diagnose HPV-positive and HPV-negative head and neck cancers

Explanatory variables Controls Patients
HPV -ve HPV + ve
n = 122 (47.8 %) n = 88 (34.5 %) n = 45 (17.7 %)
Demographics
 Gender
  Male 54 (44.3) 67 (76.1) 42 (93.3)
  Female 68 (55.7) 21 (23.9) 3 (6.7)
 Age
   < 50 66 (54.1) 8 (8.6) 7 (15.6)
  50–59 42 (34.4) 25 (26.9) 17 (37.8)
   > 60 14 (11.5) 60 (64.5) 21 (46.7)
 Race and ethnicity
  Caucasian 107 (87.7) 86 (97.7) 43 (95.6)
  Asian 8 (6.6) 0 (0) 0 (0)
  Other 7 (5.7) 2 (2.3) 2 (4.4)
Smoking
 Pack/day smoked (cigarettes, cigar or pipe)
  Non-smoker 86 (70.5) 14 (15.1) 12 (26.7)
  Ex-smoker 7 (5.8) 40 (43.0) 23 (51.1)
  1 to 19 17 (13.9) 27 (29.0) 8 (17.8)
   > 20 6 (4.9) 6 (6.5) 2 (4.4)
  Unknown 6 (4.9) 1 (1.1) 0 (0)
Drinking
 No. Of years drank >15 drinks per week
  Non-drinker 9 (7.4) 2 (2.3) 5 (11.1)
  Ex-drinker 0 (0) 3 (3.4) 4 (8.9)
  1 to 14 31 (25.4) 6 (6.8) 15 (33.3)
   > 15 3 (2.4) 11 (12.5) 7 (15.6)
  Unknown 79 (64.8) 66 (75.0) 14 (31.1)
Tumour characteristics
 AJCC TNM stage
  Stage 0   0 (0) 0 (0)
  Stage I   17 (19.3) 2 (4.4)
  Stage II   15 (17.0) 2 (4.4)
  Stage III   10 (11.4) 7 (15.6)
  Stage IVa   23 (26.1) 26 (57.8)
   Stage IVb   2 (2.3) 4 (8.9)
   Stage IVc   1 (1.1) 0 (0)
  Unknown   20 (22.7) 4 (8.9)
 Tumour anatomic site
  Oral cavity   67 (76.1) 4 (8.9)
  Oropharynx   11 (12.5) 39 (86.7)
  Hypopharynx   2 (2.3) 0 (0)
  Larynx   6 (6.8) 1 (2.2)
  Neck   2 (2.3) 1 (2.2)