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Table 1 Allele and genotype frequencies of miRNA polymorphisms among cases and controls as well as their effects on lung cancer and adenocarcinoma risk in non-smoking females

From: Polymorphisms in miR-135a-2, miR-219-2 and miR-211 as well as their interaction with cooking oil fume exposure on the risk of lung cancer in Chinese nonsmoking females: a case–control study

SNP No of controls (%) Lung cancer Lung adenocarcinoma  
No (%) OR [95 % CI] P value No (%) OR [95 % CI] P value
miR-135a-2 rs10459194
 TT 219 (82.3) 210 (78.4) 1.00 (ref)   151 (76.6) 1.00 (ref)  
 TC 46 (17.3) 56 (20.9) 1.270 (0.823–1.959) 0.281 45 (22.8) 1.419 (0.895–2.248) 0.136
 CC 1 (0.4) 2 (0.7) 2.086 (0.188–23.174) 0.550 1 (0.5) 1.450 (0.895–2.248) 0.793
TC + CC vs TT    1.287 (0.838–1.976) 0.249   1.419 (0.899–2.240) 0.132
CC vs TT + TC    1.992 (0.180–22.106) 0.574   1.352 (0.084–21.749) 0.831
 T allele 484 (91.0) 476 (88.9) 1.00 (ref)   347 (88.1) 1.00 (ref)  
 C allele 48 (9.0) 60 (11.2) 1.271 (0.852–1.896) 0.239 47 (11.9) 1.366 (0.893–2.089) 0.150
miR-219-2 rs10988341
 AA 195 (73.3) 186 (69.4) 1.00 (ref)   136 (69.0) 1.00 (ref)  
 AG 62 (23.3) 73 (27.2) 1.234 (0.833–1.830) 0.294 52 (26.4) 1.203 (0.783–1.846) 0.399
 GG 9 (3.4) 9 (3.4) 1.048 (0.407–2.699) 0.922 9 (4.6) 1.434 (0.555–3.706) 0.457
AG + GG vs AA    1.211 (0.831–1.763) 0.319   1.232 (0.821–1.849) 0.314
GG vs AA + AG    0.992 (0.388–2.540) 0.987   1.367 (0.532–3.510) 0.516
 A allele 452 (85.0) 445 (83.0) 1.00 (ref)   324 (82.2) 1.00 (ref)  
 G allele 80 (15.0) 91 (17.0) 1.155 (0.833–1.603) 0.387 70 (17.8) 1.221 (0.859–1.734) 0.265
miR-211 rs1514035
 AA 213 (80.1) 219 (81.7) 1.00 (ref)   165 (83.8) 1.00 (ref)  
 AG 48 (18.0) 43 (16.0) 0.871 (0.554–1.370) 0.551 28 (14.2) 0.753 (0.453–1.252) 0.274
 GG 5 (1.9) 6 (2.2) 1.167 (0.351–3.882) 0.801 4 (2.0) 1.033 (0.273–3.906) 0.962
AG + GG vs AA    0.899 (0.584–1.385) 0.630   0.779 (0.481–1.264) 0.312
GG vs AA + AG    1.195 (0.360–3.965) 0.770   1.082 (0.287–4.082) 0.908
 A allele 474 (89.1) 481 (89.7) 1.00 (ref)   358 (90.9) 1.00 (ref)  
 G allele 58 (10.9) 55 (10.3) 0.934 (0.633–1.380) 0.733 36 (9.1) 0.822 (0.530–1.273) 0.379
  1. Abbreviation: SNP single nucleotide polymorphism, OR odds ratio, CI confidence interval