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Table 1 Allele and genotype frequencies of miRNA polymorphisms among cases and controls as well as their effects on lung cancer and adenocarcinoma risk in non-smoking females

From: Polymorphisms in miR-135a-2, miR-219-2 and miR-211 as well as their interaction with cooking oil fume exposure on the risk of lung cancer in Chinese nonsmoking females: a case–control study

SNP

No of controls (%)

Lung cancer

Lung adenocarcinoma

 

No (%)

OR [95 % CI]

P value

No (%)

OR [95 % CI]

P value

miR-135a-2 rs10459194

 TT

219 (82.3)

210 (78.4)

1.00 (ref)

 

151 (76.6)

1.00 (ref)

 

 TC

46 (17.3)

56 (20.9)

1.270 (0.823–1.959)

0.281

45 (22.8)

1.419 (0.895–2.248)

0.136

 CC

1 (0.4)

2 (0.7)

2.086 (0.188–23.174)

0.550

1 (0.5)

1.450 (0.895–2.248)

0.793

TC + CC vs TT

  

1.287 (0.838–1.976)

0.249

 

1.419 (0.899–2.240)

0.132

CC vs TT + TC

  

1.992 (0.180–22.106)

0.574

 

1.352 (0.084–21.749)

0.831

 T allele

484 (91.0)

476 (88.9)

1.00 (ref)

 

347 (88.1)

1.00 (ref)

 

 C allele

48 (9.0)

60 (11.2)

1.271 (0.852–1.896)

0.239

47 (11.9)

1.366 (0.893–2.089)

0.150

miR-219-2 rs10988341

 AA

195 (73.3)

186 (69.4)

1.00 (ref)

 

136 (69.0)

1.00 (ref)

 

 AG

62 (23.3)

73 (27.2)

1.234 (0.833–1.830)

0.294

52 (26.4)

1.203 (0.783–1.846)

0.399

 GG

9 (3.4)

9 (3.4)

1.048 (0.407–2.699)

0.922

9 (4.6)

1.434 (0.555–3.706)

0.457

AG + GG vs AA

  

1.211 (0.831–1.763)

0.319

 

1.232 (0.821–1.849)

0.314

GG vs AA + AG

  

0.992 (0.388–2.540)

0.987

 

1.367 (0.532–3.510)

0.516

 A allele

452 (85.0)

445 (83.0)

1.00 (ref)

 

324 (82.2)

1.00 (ref)

 

 G allele

80 (15.0)

91 (17.0)

1.155 (0.833–1.603)

0.387

70 (17.8)

1.221 (0.859–1.734)

0.265

miR-211 rs1514035

 AA

213 (80.1)

219 (81.7)

1.00 (ref)

 

165 (83.8)

1.00 (ref)

 

 AG

48 (18.0)

43 (16.0)

0.871 (0.554–1.370)

0.551

28 (14.2)

0.753 (0.453–1.252)

0.274

 GG

5 (1.9)

6 (2.2)

1.167 (0.351–3.882)

0.801

4 (2.0)

1.033 (0.273–3.906)

0.962

AG + GG vs AA

  

0.899 (0.584–1.385)

0.630

 

0.779 (0.481–1.264)

0.312

GG vs AA + AG

  

1.195 (0.360–3.965)

0.770

 

1.082 (0.287–4.082)

0.908

 A allele

474 (89.1)

481 (89.7)

1.00 (ref)

 

358 (90.9)

1.00 (ref)

 

 G allele

58 (10.9)

55 (10.3)

0.934 (0.633–1.380)

0.733

36 (9.1)

0.822 (0.530–1.273)

0.379

  1. Abbreviation: SNP single nucleotide polymorphism, OR odds ratio, CI confidence interval