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Fig. 6 | BMC Cancer

Fig. 6

From: Depletion of γ-glutamylcyclotransferase inhibits breast cancer cell growth via cellular senescence induction mediated by CDK inhibitor upregulation

Fig. 6

Blockage of p16INK4A induction attenuates cell cycle arrest and growth inhibition caused by GGCT knockdown. a-b The distribution of cell cycle phases in MCF7 (A) and MDA-MB-231 (b) cells was analyzed by flow cytometry 4 days after transfection with the siRNAs indicated. c-d Representative images of MDA-MB-231 cells (c), the number of Trypan blue-negative viable MDA-MB-231 cells (d, left panel), and the proportion of dead cells (d, right panel) at 7 days after transfection with the indicated siRNAs are shown. (* p < 0.05, ** p < 0.01)

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