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Fig. 5 | BMC Cancer

Fig. 5

From: Depletion of γ-glutamylcyclotransferase inhibits breast cancer cell growth via cellular senescence induction mediated by CDK inhibitor upregulation

Fig. 5

p16INK4A regulates GGCT knockdown-induced senescence in MDA-MB-231 cells. a The expression levels of p16INK4A in MCF7 and MDA-MB-231 cells harvested 4 days after transfection with the indicated siRNAs were analyzed by western blotting. β-actin is shown as loading controls. b Representative images of SA-β-Gal staining 4 days after transfection with the indicated siRNAs in MCF7 and MDA231-MB cells. Scale bar represents 50 μm. c The number of SA-β-Gal positive cells was counted and their ratios in total cells are shown. (** p < 0.01)

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