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Fig. 4 | BMC Cancer

Fig. 4

From: Depletion of γ-glutamylcyclotransferase inhibits breast cancer cell growth via cellular senescence induction mediated by CDK inhibitor upregulation

Fig. 4

Upregulation of p21WAF1/CIP1 is critical for G0/G1 arrest and consequent growth inhibition by GGCT knockdown. a-b The distribution of cell cycle phases in MCF7 cells was analyzed by flow cytometry 4 days after transfection with the indicated siRNAs. Representative histograms (a) and quantified distributions are shown (b). c-d The number of Trypan blue-negative viable MCF cells (c) and the proportion of dead cells (d) at 7 days after transfection with the indicated siRNAs are shown. (* p < 0.05, ** p < 0.01)

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