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Fig. 1 | BMC Cancer

Fig. 1

From: Depletion of γ-glutamylcyclotransferase inhibits breast cancer cell growth via cellular senescence induction mediated by CDK inhibitor upregulation

Fig. 1

GGCT knockdown suppresses the growth of MCF7 and MDA-MB-231 cells. a MCF7 and MDA-MB-231 cells were transfected with siRNA targeting GGCT or non-target control siRNA, and the expression levels of GGCT in total cell lysates harvested 4 days after the transfection were analyzed by Western blotting. β-actin is shown as a loading control. b MCF7 and MDA-MB-231 cells were treated with GGCT siRNA or non-target siRNA. The relative number of trypan blue-negative viable cells at 1, 4, and 7 days after the transfection are shown. c Proportion of trypan blue-positive dead cells at 6 days after transfection. (** p < 0.01)

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