From: Influence of dosing times on cisplatin-induced peripheral neuropathy in rats
Groups | CDDP concentration (μg/mL) | ||||||||
---|---|---|---|---|---|---|---|---|---|
5Â min | 15Â min | 30Â min | 60Â min | 120Â min | 240Â min | 360Â min | 480Â min | 720Â min | |
The first administration | |||||||||
 5:00 | 4.62 ± 0.49 | 3.58 ± 0.17 | 1.90 ± 0.13 | 0.87 ± 0.07 | 0.72 ± 0.03 | 0.65 ± 0.05 | 0.63 ± 0.02 | 0.60 ± 0.01 | 0.52 ± 0.02 |
 17:00 | 4.84 ± 0.44 | 3.68 ± 0.26 | 1.93 ± 0.15 | 0.86 ± 0.05 | 0.71 ± 0.06 | 0.66 ± 0.04 | 0.61 ± 0.03 | 0.57 ± 0.03 | 0.52 ± 0.05 |
The fourth administration | |||||||||
 5:00 | 6.75 ± 0.59 | 5.34 ± 0.27 | 3.79 ± 0.20 | 2.71 ± 0.20 | 1.74 ± 0.10 | 1.52 ± 0.13 | 1.34 ± 0.11 | 1.12 ± 0.09 | 1.12 ± 0.04 |
 17:00 | 7.38 ± 0.24 | 5.13 ± 0.21 | 3.81 ± 0.10 | 2.14 ± 0.09* | 1.32 ± 0.05** | 1.16 ± 0.06* | 1.03 ± 0.07* | 0.97 ± 0.06 | 0.89 ± 0.04** |