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Table 2 Influence of dosing time on serum CDDP concentrations after the first or fourth administration of CDDP to rats

From: Influence of dosing times on cisplatin-induced peripheral neuropathy in rats

Groups CDDP concentration (μg/mL)
5 min 15 min 30 min 60 min 120 min 240 min 360 min 480 min 720 min
The first administration
 5:00 4.62 ± 0.49 3.58 ± 0.17 1.90 ± 0.13 0.87 ± 0.07 0.72 ± 0.03 0.65 ± 0.05 0.63 ± 0.02 0.60 ± 0.01 0.52 ± 0.02
 17:00 4.84 ± 0.44 3.68 ± 0.26 1.93 ± 0.15 0.86 ± 0.05 0.71 ± 0.06 0.66 ± 0.04 0.61 ± 0.03 0.57 ± 0.03 0.52 ± 0.05
The fourth administration
 5:00 6.75 ± 0.59 5.34 ± 0.27 3.79 ± 0.20 2.71 ± 0.20 1.74 ± 0.10 1.52 ± 0.13 1.34 ± 0.11 1.12 ± 0.09 1.12 ± 0.04
 17:00 7.38 ± 0.24 5.13 ± 0.21 3.81 ± 0.10 2.14 ± 0.09* 1.32 ± 0.05** 1.16 ± 0.06* 1.03 ± 0.07* 0.97 ± 0.06 0.89 ± 0.04**
  1. Each value represents the mean with S.E.M. (n = 6), *: P < 0.05, and **: P < 0.01 using the Student’s t-test