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Table 2 Influence of dosing time on serum CDDP concentrations after the first or fourth administration of CDDP to rats

From: Influence of dosing times on cisplatin-induced peripheral neuropathy in rats

Groups

CDDP concentration (μg/mL)

5 min

15 min

30 min

60 min

120 min

240 min

360 min

480 min

720 min

The first administration

 5:00

4.62 ± 0.49

3.58 ± 0.17

1.90 ± 0.13

0.87 ± 0.07

0.72 ± 0.03

0.65 ± 0.05

0.63 ± 0.02

0.60 ± 0.01

0.52 ± 0.02

 17:00

4.84 ± 0.44

3.68 ± 0.26

1.93 ± 0.15

0.86 ± 0.05

0.71 ± 0.06

0.66 ± 0.04

0.61 ± 0.03

0.57 ± 0.03

0.52 ± 0.05

The fourth administration

 5:00

6.75 ± 0.59

5.34 ± 0.27

3.79 ± 0.20

2.71 ± 0.20

1.74 ± 0.10

1.52 ± 0.13

1.34 ± 0.11

1.12 ± 0.09

1.12 ± 0.04

 17:00

7.38 ± 0.24

5.13 ± 0.21

3.81 ± 0.10

2.14 ± 0.09*

1.32 ± 0.05**

1.16 ± 0.06*

1.03 ± 0.07*

0.97 ± 0.06

0.89 ± 0.04**

  1. Each value represents the mean with S.E.M. (n = 6), *: P < 0.05, and **: P < 0.01 using the Student’s t-test