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Table 1 Time courses of paw withdrawal thresholds and withdrawal latency during the weekly administration of CDDP to rats

From: Influence of dosing times on cisplatin-induced peripheral neuropathy in rats

Behavioral test Groups Time before/after the first administration (days)
−1 6 13 20 27
von-Frey test Control 51.5 ± 5.6 g 51.5 ± 5.6 g 47.3 ± 6.2 g 45.9 ± 7.0 g 51.5 ± 5.6 g
CDDP 55.8 ± 4.3 g 15.9 ± 2.4 g** 40.3 ± 7.6 g 56.5 ± 8.3 g 70.8 ± 9.5 g
Hot-plate test Control 15.9 ± 1.5 sec 14.5 ± 0.4 sec - - 14.4 ± 1.4 sec
CDDP 14.4 ± 1.8 sec 9.7 ± 0.9 sec** - - 37.1 ± 7.3 sec*
  1. Each data represent the mean with S.E.M. in the von-Frey test (n = 8) and in the hot-plate test (n = 4), *: P < 0.05, and **: P < 0.01 using the Student’s t-test