Hypoxia promotes chemoresistance in acute lymphoblastic leukemia cell lines by modulating death signaling pathways

Petit, C.; Gouel, F.; Dubus, I.; Heuclin, C.; Roget, K.; Vannier, J. P.

doi:10.1186/s12885-016-2776-1

Table 1 Summary chart of results obtained in this study

From: Hypoxia promotes chemoresistance in acute lymphoblastic leukemia cell lines by modulating death signaling pathways

Nalm-6 no treatment
	Cell density	Cell proliferation	Cell viability (%)	MCL-1 protein expression	Bcl-2 protein expression	Bim protein expression
Normoxa	More important	Equal	Equal	Weakly expressed	Weakly expressed	Overexpressed
Hypoxia	Less important	Equal	Equal	Overexpressed	Overexpressed	under expressed
Nalm-6 treated MTX
	Cell density	Cell proliferation	Cell viability (%)	MCL-1 protein expression	Bcl-2 protein expression	Bim protein expression
Normoxa	inhibited by MTX	inhibited by MTX	inhibited by MTX	Overexpressed	Overexpressed	Equal
Hypoxia	inhibited by MTX	inhibited by MTX	Less inhibited	strongly expressed	strongly expressed	Equal
Nalm-6 treated PRD
	Cell density	Cell proliferation	Cell viability (%)	MCL-1 protein expression	Bcl-2 protein expression	Bim protein expression
	inhibited by PRD	Equal	inhibited by PRD	Overexpressed	Overexpressed	Equal
	inhibited by PRD	Equal	Less inhibited	strongly expressed	strongly expressed	Equal
Reh no treatment
	Cell density	Cell proliferation	Cell viability (%)	MCL-1 protein expression	Bcl-2 protein expression	Bim protein expression
Normoxia	More important	Equal	Equal	Overexpressed	Overexpressed	Equal
Hypoxia	Less important	Equal	Equal	strongly expressed	strongly expressed	Equal
Reh treated MTX
	Cell density	Cell proliferation	Cell viability (%)	MCL-1 protein expression	Bcl-2 protein expression	Bim protein expression
Normoxia	inhibited by MTX	inhibited by MTX	inhibited by MTX	Overexpressed	Overexpressed	Equal
Hypoxia	inhibited by MTX	inhibited by MTX	inhibited by MTX	strongly expressed	strongly expressed	Equal
Reh treated PRD
	Cell density	Cell proliferation	Cell viability (%)	MCL-1 protein expression	Bcl-2 protein expression	Bim protein expression
Normoxia	inhibited by PRD	Equal	inhibited by PRD	Overexpressed	Overexpressed	Equal
Hypoxia	inhibited by PRD	Equal	Less inhibited	strongly expressed	strongly expressed	Equal

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ISSN: 1471-2407

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