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Table 1 Summary chart of results obtained in this study

From: Hypoxia promotes chemoresistance in acute lymphoblastic leukemia cell lines by modulating death signaling pathways

Nalm-6 no treatment
  Cell density Cell proliferation Cell viability (%) MCL-1 protein expression Bcl-2 protein expression Bim protein expression
Normoxa More important Equal Equal Weakly expressed Weakly expressed Overexpressed
Hypoxia Less important Equal Equal Overexpressed Overexpressed under expressed
Nalm-6 treated MTX
  Cell density Cell proliferation Cell viability (%) MCL-1 protein expression Bcl-2 protein expression Bim protein expression
Normoxa inhibited by MTX inhibited by MTX inhibited by MTX Overexpressed Overexpressed Equal
Hypoxia inhibited by MTX inhibited by MTX Less inhibited strongly expressed strongly expressed Equal
Nalm-6 treated PRD
  Cell density Cell proliferation Cell viability (%) MCL-1 protein expression Bcl-2 protein expression Bim protein expression
  inhibited by PRD Equal inhibited by PRD Overexpressed Overexpressed Equal
  inhibited by PRD Equal Less inhibited strongly expressed strongly expressed Equal
Reh no treatment
  Cell density Cell proliferation Cell viability (%) MCL-1 protein expression Bcl-2 protein expression Bim protein expression
Normoxia More important Equal Equal Overexpressed Overexpressed Equal
Hypoxia Less important Equal Equal strongly expressed strongly expressed Equal
Reh treated MTX
  Cell density Cell proliferation Cell viability (%) MCL-1 protein expression Bcl-2 protein expression Bim protein expression
Normoxia inhibited by MTX inhibited by MTX inhibited by MTX Overexpressed Overexpressed Equal
Hypoxia inhibited by MTX inhibited by MTX inhibited by MTX strongly expressed strongly expressed Equal
Reh treated PRD
  Cell density Cell proliferation Cell viability (%) MCL-1 protein expression Bcl-2 protein expression Bim protein expression
Normoxia inhibited by PRD Equal inhibited by PRD Overexpressed Overexpressed Equal
Hypoxia inhibited by PRD Equal Less inhibited strongly expressed strongly expressed Equal