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Table 1 Differentially expressed significant genes in RCC

From: Cyclin D1 as a therapeutic target of renal cell carcinoma- a combined transcriptomics, tissue microarray and molecular docking study from the Kingdom of Saudi Arabia

Gene symbol Gene name RefSeq p-value Fold-change
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 NM_001040708 7.88E-06 3.64128
NRP2 neuropilin 2 ENST00000272849 0.00017 3.63215
LEF1 lymphoid enhancer-binding factor 1 NM_001130713 4.04E-05 3.54448
HIST1H3H histone cluster 1, H3h NM_003536 3.29E-05 2.87948
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) NM_000887 3.23E-05 2.69367
BUB1 BUB1 mitotic checkpoint serine NM_001278616 3.35E-05 2.62163
MAP3K7CL MAP3K7 C-terminal like NM_001286620 2.81E-05 2.54523
FXYD5 FXYD domain containing ion transport regulator 5 NM_001164605 0.000158 2.45618
HIST1H2AI histone cluster 1, H2ai NM_003509 0.000108 2.27918
CENPK centromere protein K NM_001267038 6.01E-05 2.27502
CCND1 cyclin D1 NM_053056 0.004789 2.25898
DDX11 DEAD NM_001257144 0.000178 2.24119
APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-li NM_152426 2.61E-06 2.23905
ATAD2 ATPase family, AAA domain containing 2 NM_014109 0.000129 2.18905
HIST1H3F histone cluster 1, H3f NM_021018 0.00016 2.14196
TREM2 triggering receptor expressed on myeloid cells 2 NM_018965 0.00021 2.13092
GAL3ST4 galactose-3-O-sulfotransferase 4 NM_024637 1.50E-05 2.11736
LOC400464 uncharacterized LOC400464 AK127420 9.33E-05 2.11281
CXCL11 chemokine (C-X-C motif) ligand 11 NM_005409 0.0002 2.07422
NEIL3 nei endonuclease VIII-like 3 (E. coli) NM_018248 2.73E-05 2.06874
EVL Enah ENST00000553771 5.57E-05 2.06506
SLFN12L schlafen family member 12-like ENST00000361112 9.07E-05 2.02832
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 NM_001161504 4.94E-07 −16.1809
SLC22A12 solute carrier family 22 (organic anion NM_001276326 9.50E-06 −16.4997
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), me NM_001099646 5.60E-06 −17.2214
HAO2 hydroxyacid oxidase 2 (long chain) NM_001005783 0.000192 −17.3322
SLC6A19 solute carrier family 6 (neutral amino acid transporter), me NM_001003841 0.000195 −18.4585
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound NM_003399 0.000131 −18.9386
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 XR_246241 7.59E-05 −19.2237
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 NM_004790 5.33E-06 −20.6522
KCNJ1 potassium inwardly-rectifying channel, subfamily J, member 1 NM_000220 8.79E-05 −22.4359
TMEM52B transmembrane protein 52B NM_001079815 0.000112 −23.1374
SLC12A3 solute carrier family 12 (sodium NM_000339 1.14E-06 −27.7638
HPD 4-hydroxyphenylpyruvate dioxygenase NM_001171993 1.88E-05 −29.7949
SLC5A12 solute carrier family 5 (sodium XM_006718157 0.000155 −30.9613
KNG1 kininogen 1 NM_000893 4.28E-06 −34.7144
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate tra NM_001011554 1.93E-06 −37.6483
SLC36A2 solute carrier family 36 (proton NM_181776 4.06E-07 −37.8957
PLG plasminogen NM_000301 4.87E-07 −43.0535
SLC22A8 solute carrier family 22 (organic anion transporter), member NM_001184732 4.50E-06 −45.8474
UMOD uromodulin NM_001008389 2.44E-06 −68.9599
CALB1 calbindin 1, 28 kDa NM_004929 2.29E-06 −78.3947
SLC12A1 solute carrier family 12 ENST00000330289 0.000135 −79.6698
ALDOB aldolase B, fructose-bisphosphate NM_000035 2.56E-05 −87.9122
  1. Negative fold change value indicates the downregulation
  2. *bold data shows CCND1 (Cyclin D1) was overexpressed (fold change = 2.258) and statistically significant (p-value = 0.00478)