Table 3 Grade 3 to 4 adverse events of interest

Anemia

0.0 %

0.83–1.24

0.883

Thrombocytopenia

39.2 %

0.74–1.51

0.771

Leucopenia

66.1 %

0.73–2.10

0.433

Neutropenia

85.8 %

0.88–2.01

0.179

Febrile neutropenia

67.2 %

0.68–2.67

0.401

Hypokalemia

38.1 %

0.81–1.47

0.586

Rash

0.0 %

6.81–70.02

<0.001*

Hand-foot syndrome

37.6 %

1.22–2.50

0.002*

Stomatitis

42.8 %

1.23–3.51

0.006*

Nausea

21.6 %

0.73–1.21

0.639

Vomit

0.3 %

0.79–1.25

0.944

Abdominal pain

0.0 %

0.47–2.57

0.821

Diarrhea

14.1 %

1.88–3.06

<0.001*

Constipation

0.0 %

0.08–0.91

0.034*

Decreased appetite

0.0 %

0.88–1.46

0.342

Fatigue

0.0 %

1.21–2.00

0.001*

Neuropathy

62.8 %

0.24–2.41

0.636

Any adverse events

86.8 %

0.98–2.40

0.062