From: Development of prognostic signatures for intermediate-risk papillary thyroid cancer
Factor | Â | Poor prognosis % (n) | Good Prognosis % (n) | P-valuea (different frequency between prognostic groups) | |
---|---|---|---|---|---|
Extra-thyroid extension | N total | 144 | 130 | 0.001 | |
With extentions | 32Â % (47) | 15Â % (19) | |||
Nodal involvement | N total | 127 | 114 | <0.001 | |
with nodal involvement | 65Â % (83) | 35Â % (40) | |||
Clinical stage | N total | 144 | 135 | 0.08 | |
Stage 1 | 22Â % (32) | 22Â % (30) | |||
Stage 2 | 40Â % (58) | 52Â % (70) | |||
Stage 3 | 38Â % (54) | 26Â % (35) | |||
Histological subtype | N total | 179 | 142 | <0.001 | |
Classical | 80 (144) | 54 (77) | |||
Follicular | 5 (9) | 44 (62) | |||
Tall cell | 15 (26) | 2 (3) | |||
Age at diagnosis | N total | 184 | 143 | 0.41 | |
less than 45Â years | 50 (92) | 45 (64) | |||
Gender | N total | 184 | 143 | 0.7834 | |
Female | 72Â % (132) | 76Â % (108) | |||
Male | 28Â % (52) | 24Â % (35) | |||
Race | N total | 154 | 55 | 0.544 | |
Asian | 11Â % (17) | 14Â % (8) | |||
Black/African American (n) | 7Â % (11) | 4Â % (2) | |||
White | 82Â % (126) | 82Â % (45) | |||
Mutations | BRAF | N total | 162 | 124 | <0.001 |
With mutations | 85Â % (137) | 21Â % (26) | |||
HRAS | N total | 162 | 124 | <0.001 | |
With mutations | 0Â % | 9Â % (11) | |||
KRAS | N total | 162 | 124 | 0.36 | |
With mutations | 0Â % | 2Â % (2) | |||
NRAS | N total | 162 | 124 | <0.001 | |
With mutations | 2Â % (4) | 15Â % (19) |