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Table 1 Distribution of clinicopathologic and demographic factors in intermediate risk patients classified as good or poor prognosis by PAM model

From: Development of prognostic signatures for intermediate-risk papillary thyroid cancer

Factor   Poor prognosis % (n) Good Prognosis % (n) P-valuea (different frequency between prognostic groups)
Extra-thyroid extension N total 144 130 0.001
With extentions 32 % (47) 15 % (19)
Nodal involvement N total 127 114 <0.001
with nodal involvement 65 % (83) 35 % (40)
Clinical stage N total 144 135 0.08
Stage 1 22 % (32) 22 % (30)
Stage 2 40 % (58) 52 % (70)
Stage 3 38 % (54) 26 % (35)
Histological subtype N total 179 142 <0.001
Classical 80 (144) 54 (77)
Follicular 5 (9) 44 (62)
Tall cell 15 (26) 2 (3)
Age at diagnosis N total 184 143 0.41
less than 45 years 50 (92) 45 (64)
Gender N total 184 143 0.7834
Female 72 % (132) 76 % (108)
Male 28 % (52) 24 % (35)
Race N total 154 55 0.544
Asian 11 % (17) 14 % (8)
Black/African American (n) 7 % (11) 4 % (2)
White 82 % (126) 82 % (45)
Mutations BRAF N total 162 124 <0.001
With mutations 85 % (137) 21 % (26)
HRAS N total 162 124 <0.001
With mutations 0 % 9 % (11)
KRAS N total 162 124 0.36
With mutations 0 % 2 % (2)
NRAS N total 162 124 <0.001
With mutations 2 % (4) 15 % (19)
  1. a(Pearson chi-squared (categorical variables), or Student’s T-test (continous variables)