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Table 4 Multivariate Cox proportional hazard models for the predictors of overall survival

From: Favorable prognosis in colorectal cancer patients with co-expression of c-MYC and ß-catenin

Factors Univariate survival analysis Multivariate survival analysis
HR (95 % CI) P value HR (95 % CI) P value
Cohort 1
co-expression of c-MYC and ß-catenin 0.482 (0.310–0.749) 0.012 0.629 (0.397–0.996) 0.048
 Age 1.026 (1.008–1.045) 0.005 1.022 (1.004–1.040) 0.015
 Size 1.244 (1.059–1.244) 0.001 1.049 (0.946–1.163) NS (0.362)
 Histologic grade (high vs. low) 3.143 (1.904–5.188) <0.001 2.842 (1.608–5.023) <0.001
 Stage (3/4 vs. 1/2) 6.151 (3.494–10.829) <0.001 2.942 (1.538–5.628) 0.001
 Lymphatic invasion 3.661 (2.242–5.980) <0.001 1.338 (0.763–2.349) NS (0.310)
 Perineural invasion 3.942 (2.648–5.870) <0.001 2.337 (1.487–3.673) <0.001
 Venous invasion 3.985 (2.671–5.946) <0.001 2.163 (1.390–3.366) 0.001
c-MYC mRNA expression 0.599 (0.403–0.891) 0.011 0.703 (0.464–1.066) NS (0.097)
 Age 1.026 (1.008–1.045) 0.005 1.024 (1.006–1.042) 0.008
 Size 1.244 (1.059–1.244) 0.001 1.056 (0.953–1.169) NS (0.297)
 Histologic grade (high vs. low) 3.143 (1.904–5.188) <0.001 2.785 (1.562–4.968) 0.001
 Stage (3/4 vs. 1/2) 6.151 (3.494–10.829) <0.001 3.017 (1.574–5.782) 0.001
 Lymphatic invasion 3.661 (2.242–5.980) <0.001 1.327 (0.756–2.330) NS (0.324)
 Perineural invasion 3.942 (2.648–5.870) <0.001 2.438 (1.554–3.827) <0.001
 Venous invasion 3.985 (2.671–5.946) <0.001 2.102 (1.356–3.259) 0.001
c-MYC protein expression 0.593 (0.400–0.880) 0.010 0.751 (0.498–1.132) NS (0.171)
 Age 1.026 (1.008–1.045) 0.005 1.023 (1.005–1.041) 0.012
 Size 1.244 (1.059–1.244) 0.001 1.054 (0.951–1.169) NS (0.317)
 Histologic grade (high vs. low) 3.143 (1.904–5.188) <0.001 2.967 (1.681–5.236) <0.001
 Stage (3/4 vs. 1/2) 6.151 (3.494–10.829) <0.001 2.959 (1.549–5.653) 0.001
 Lymphatic invasion 3.661 (2.242–5.980) <0.001 1.344 (0.766–2.356) NS (0.303)
 Perineural invasion 3.942 (2.648–5.870) <0.001 2.388 (1.522–3.746) <0.001
 Venous invasion 3.985 (2.671–5.946) <0.001 2.105 (1.356–3.269) 0.001
ß-catenin protein expression 0.666 (0.449–0.986) 0.042 0.740 (0.497–1.101) NS (0.138)
 Age 1.026 (1.008–1.045) 0.005 1.023 (1.005–1.041) 0.012
 Size 1.244 (1.059–1.244) 0.001 1.068 (0.966–1.180) NS (0.197)
 Histologic grade (high vs. low) 3.143 (1.904–5.188) <0.001 2.897 (1.645–5.102) <0.001
 Stage (3/4 vs. 1/2) 6.151 (3.494–10.829) <0.001 3.034 (1.587–5.801) 0.001
 Lymphatic invasion 3.661 (2.242–5.980) <0.001 1.356 (0.771–2.383) NS (0.290)
 Perineural invasion 3.942 (2.648–5.870) <0.001 2.367 (1.508–3.717) <0.001
 Venous invasion 3.985 (2.671–5.946) <0.001 2.071 (1.331–3.224) 0.001
Primary tumor of cohort 2
co-expression of c-MYC and ß-catenin 0.430 (0.254–0.726) 0.001 0.440 (0.259–0.747) 0.002
 Age 1.023 (1.001–1.045) 0.037 1.025 (1.004–1.047) 0.020
 Stage (3/4 vs. 1/2) 7.894 (1.922–32.418) 0.004 5.731 (1.380–23.800) 0.016
 Lymphatic invasion 2.480 (1.402–4.386) 0.002 1.712 (0.940–3.117) NS (0.079)
 Perineural invasion 2.119 (1.313–3.421) 0.002 1.724 (1.049–2.831) 0.032
  1. P-values are calculated by using χ2-test or Fisher’s exact test
  2. Abbreviations: HR hazard ratio