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Table 2 The clinicopathologic parameters of 176 advanced CRC patients with synchronous or metachronous metastases (cohort2)

From: Favorable prognosis in colorectal cancer patients with co-expression of c-MYC and ß-catenin

  Total (n = 176) Metastasis
Synchronous (n = 118) Metachronous (n = 58) P-Value
Sex male 96 56 (47.5 %) 40 (69.0 %) 0.006
female 80 62 (52.5 %) 18 (31.0 %)
Metastatic site liver 82 61 (52.1 %) 21 (36.2 %) <0.001
lung 37 10 (8.5 %) 27 (46.6 %)
peritoneal seeding 38 32 (26.5 %) 6 (10.3 %)
distant lymph node 3 2 (1.7 %) 1 (1.7 %)
ovary 16 13 (11.1 %) 3 (5.2 %)
Location of primary tumor appendix 1 1 (0.9 %) 0 (0.0 %) 0.293
cecum 7 7 (6.0 %) 0 (0.0 %)
ascending colon 17 14 (12.0 %) 3 (5.2 %)
hepatic flexure 13 9 (7.7 %) 4 (6.9 %)
transverse colon 9 7 (6.0 %) 2 (3.4 %)
splenic flexure 7 4 (3.4 %) 3 (5.2 %)
descending colon 8 6 (5.1 %) 2 (3.4 %)
sigmoid colon 50 28 (23.9 %) 22 (37.9 %)
rectum 64 42 (35.0 %) 22 (37.9 %)
T stage T1 1 1 (0.9 %) 0 (0.0 %) <0.001
T2 3 1 (0.9 %) 2 (3.4 %)
T3 107 60 (50.4 %) 47 (81.0 %)
T4 65 56 (47.9 %) 9 (15.5 %)
N stage N0 34 13 (11.1 %) 21 (36.2 %) <0.001
N1 62 37 (31.6 %) 25 (43.1 %)
N2 80 68 (57.3 %) 12 (20.7 %)
Stage I 2 0 (0.0 %) 2 (3.4 %) <0.001
II 18 0 (0.0 %) 18 (31.0 %)
III 45 8 (6.8 %) 37 (63.8 %)
IV 111 110 (93.2 %) 1 (1.7 %)
Differentiation low grade 158 104 (88.0 %) 54 (93.1 %) 0.299
high grade 18 14 (12.0 %) 4 (6.9 %)
Lymphatic invasion absent 62 38 (32.5 %) 24 (41.4 %) 0.247
present 114 80 (67.5 %) 34 (58.6 %)
Venous invasion absent 123 77 (65.0 %) 46 (79.3 %) 0.052
present 53 41 (35.0 %) 12 (20.7 %)
Perineural invasion absent 90 56 (47.9 %) 34 (58.6 %) 0.180
present 86 62 (52.1 %) 24 (41.4 %)
Tumor border expanding 13 6 (5.1 %) 7 (12.1 %) 0.099
infiltrative 163 112 (94.9 %) 51 (87.9 %)
  1. P-values are calculated by using χ2-test or Fisher’s exact test
  2. Abbreviations: T tumor; N lymph node