Table 2 The clinicopathologic parameters of 176 advanced CRC patients with synchronous or metachronous metastases (cohort2)
From: Favorable prognosis in colorectal cancer patients with co-expression of c-MYC and ß-catenin
Total (n = 176) | Metastasis | ||||
|---|---|---|---|---|---|
Synchronous (n = 118) | Metachronous (n = 58) | P-Value | |||
Sex | male | 96 | 56 (47.5 %) | 40 (69.0 %) | 0.006 |
female | 80 | 62 (52.5 %) | 18 (31.0 %) | ||
Metastatic site | liver | 82 | 61 (52.1 %) | 21 (36.2 %) | <0.001 |
lung | 37 | 10 (8.5 %) | 27 (46.6 %) | ||
peritoneal seeding | 38 | 32 (26.5 %) | 6 (10.3 %) | ||
distant lymph node | 3 | 2 (1.7 %) | 1 (1.7 %) | ||
ovary | 16 | 13 (11.1 %) | 3 (5.2 %) | ||
Location of primary tumor | appendix | 1 | 1 (0.9 %) | 0 (0.0 %) | 0.293 |
cecum | 7 | 7 (6.0 %) | 0 (0.0 %) | ||
ascending colon | 17 | 14 (12.0 %) | 3 (5.2 %) | ||
hepatic flexure | 13 | 9 (7.7 %) | 4 (6.9 %) | ||
transverse colon | 9 | 7 (6.0 %) | 2 (3.4 %) | ||
splenic flexure | 7 | 4 (3.4 %) | 3 (5.2 %) | ||
descending colon | 8 | 6 (5.1 %) | 2 (3.4 %) | ||
sigmoid colon | 50 | 28 (23.9 %) | 22 (37.9 %) | ||
rectum | 64 | 42 (35.0 %) | 22 (37.9 %) | ||
T stage | T1 | 1 | 1 (0.9 %) | 0 (0.0 %) | <0.001 |
T2 | 3 | 1 (0.9 %) | 2 (3.4 %) | ||
T3 | 107 | 60 (50.4 %) | 47 (81.0 %) | ||
T4 | 65 | 56 (47.9 %) | 9 (15.5 %) | ||
N stage | N0 | 34 | 13 (11.1 %) | 21 (36.2 %) | <0.001 |
N1 | 62 | 37 (31.6 %) | 25 (43.1 %) | ||
N2 | 80 | 68 (57.3 %) | 12 (20.7 %) | ||
Stage | I | 2 | 0 (0.0 %) | 2 (3.4 %) | <0.001 |
II | 18 | 0 (0.0 %) | 18 (31.0 %) | ||
III | 45 | 8 (6.8 %) | 37 (63.8 %) | ||
IV | 111 | 110 (93.2 %) | 1 (1.7 %) | ||
Differentiation | low grade | 158 | 104 (88.0 %) | 54 (93.1 %) | 0.299 |
high grade | 18 | 14 (12.0 %) | 4 (6.9 %) | ||
Lymphatic invasion | absent | 62 | 38 (32.5 %) | 24 (41.4 %) | 0.247 |
present | 114 | 80 (67.5 %) | 34 (58.6 %) | ||
Venous invasion | absent | 123 | 77 (65.0 %) | 46 (79.3 %) | 0.052 |
present | 53 | 41 (35.0 %) | 12 (20.7 %) | ||
Perineural invasion | absent | 90 | 56 (47.9 %) | 34 (58.6 %) | 0.180 |
present | 86 | 62 (52.1 %) | 24 (41.4 %) | ||
Tumor border | expanding | 13 | 6 (5.1 %) | 7 (12.1 %) | 0.099 |
infiltrative | 163 | 112 (94.9 %) | 51 (87.9 %) | ||