Table 1 Tumor and women’s characteristics, treatments performed and frequencies of complications, according to detection method
Screen-detected cancers | Interval cancers | P-value | Total | ||||
|---|---|---|---|---|---|---|---|
N | % | N | % | N | % | ||
Total women | 732 | 69.3 | 325 | 30.7 | 1057 | 100.0 | |
Tumor size (n = 936) | <0.001 | ||||||
< = 10 mm | 198 | 31.9 | 40 | 12.7 | 238 | 25.4 | |
11 to 20 mm | 273 | 44.0 | 117 | 37.0 | 390 | 41.7 | |
21 to 50 mm | 132 | 21.3 | 133 | 42.1 | 265 | 28.3 | |
> 50 mm | 17 | 2.7 | 26 | 8.2 | 43 | 4.6 | |
Lymph node involvement (n = 1054) | <0.001 | ||||||
Negative | 542 | 74.2 | 180 | 55.6 | 722 | 68.5 | |
Positive | 188 | 25.8 | 144 | 44.4 | 332 | 31.5 | |
Number of positive nodes (n = 870) | <0.05 | ||||||
= <3 | 515 | 92.5 | 268 | 85.6 | 783 | 90.0 | |
4–20 | 38 | 6.8 | 41 | 13.1 | 79 | 9.1 | |
> 20 | 4 | 0.7 | 4 | 1.3 | 8 | 0.9 | |
Histological type (n = 1050) | <0.001 | ||||||
Ductal Infiltrante | 531 | 72.7 | 242 | 75.6 | 773 | 73.6 | |
Ductal In situ | 81 | 11.1 | 12 | 3.8 | 93 | 8.9 | |
Lobular | 63 | 8.6 | 36 | 11.3 | 99 | 9.4 | |
Otros | 55 | 7.5 | 30 | 9.4 | 85 | 8.1 | |
Focality (n = 894) | 0.643 | ||||||
Unifocal | 487 | 83.5 | 256 | 82.3 | 743 | 83.1 | |
Multifocal and/or multicentric | 96 | 16.5 | 55 | 17.7 | 151 | 16.9 | |
Histological grade (n = 914) | <0.001 | ||||||
I | 181 | 28.8 | 48 | 16.8 | 229 | 25.1 | |
II | 249 | 39.6 | 104 | 36.4 | 353 | 38.6 | |
III | 152 | 24.2 | 121 | 42.3 | 273 | 29.9 | |
Not applicable | 46 | 7.3 | 13 | 4.5 | 59 | 6.5 | |
Tumor phenotype (n = 769) | <0.001 | ||||||
Luminal A | 275 | 56.9 | 132 | 46.2 | 407 | 52.9 | |
Luminal B | 131 | 27.1 | 79 | 27.6 | 210 | 27.3 | |
HER2 | 38 | 7.9 | 29 | 10.1 | 67 | 8.7 | |
Triple negative | 39 | 8.1 | 46 | 16.1 | 85 | 11.1 | |
Age (n = 1057) | <0.001 | ||||||
50–54 | 193 | 26.4 | 117 | 36.0 | 310 | 29.3 | |
55–59 | 183 | 25.0 | 100 | 30.8 | 283 | 26.8 | |
60–64 | 211 | 28.8 | 67 | 20.6 | 278 | 26.3 | |
65–70 | 145 | 19.8 | 41 | 12.6 | 186 | 17.6 | |
Charlson index (n = 1057) | 0.380 | ||||||
0 | 535 | 73.1 | 241 | 74.2 | 776 | 73.4 | |
1 | 129 | 17.6 | 53 | 16.3 | 182 | 17.2 | |
> =2 | 68 | 9.3 | 31 | 9.5 | 99 | 9.4 | |
Surgery (n = 1055) | <0.001 | ||||||
Radical | 119 | 16.3 | 107 | 33.0 | 226 | 21.4 | |
Conservative | 612 | 83.7 | 217 | 67.0 | 829 | 78.6 | |
Axillary treatment: SLNB and ALNDc (n = 994) | <0.05 | ||||||
Only SLNB | 201 | 29.4 | 67 | 21.7 | 268 | 27.0 | |
ALND | 483 | 70.6 | 243 | 78.4 | 726 | 73.0 | |
Neoadjuvant therapy (n = 1057) | <0.001 | ||||||
No | 701 | 95.8 | 247 | 76.0 | 948 | 89.7 | |
Yes | 31 | 4.2 | 78 | 24.0 | 109 | 10.3 | |
Adjuvant therapy (n = 1051) | 0.387 | ||||||
No | 16 | 2.2 | 10 | 3.1 | 26 | 2.5 | |
Yes | 712 | 97.8 | 313 | 96.9 | 1025 | 97.5 | |
Any complicationa (n = 1057) | 225 | 30.7 | 88 | 27.1 | 0.229 | 313 | 29.6 |
Persistent painb (n = 1045) | 93 | 12.9 | 25 | 7.8 | <0.05 | 118 | 11.3 |