Table 1 Inclusion and Exclusion Criteria

• Patients receiving anthracycline or trastuzumab-based chemotherapy.

• Histologically confirmed malignancy;

• Age > 18 years, and

• No contraindication to MRI.

• Physical disability preventing exercise testing or DEXA scan;

• Psychiatric disease or disorder precluding informed consent;

• Contraindication to anti-cancer therapy, including known heart failure, cardiomyopathy, or baseline LV ejection fraction less than 50 %;

• Previous anthracycline or trastuzumab-based therapy;

• Previous radiotherapy to thorax.