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Fig. 6 | BMC Cancer

Fig. 6

From: CD44 and RHAMM are essential for rapid growth of bladder cancer driven by loss of Glycogen Debranching Enzyme (AGL)

Fig. 6

Relationship of CD44, RHAMM and AGL mRNA to clinicopathologic variables in human bladder cancer. a, b CD44 and RHAMM mRNA expression in high grade (HG) and muscle invasive (MI) bladder tumors compared to low grade (LG) and non-muscle invasive (NMI) bladder tumors in two independent patient datasets (i) Stransky et al. [11] and (ii) Kim et al. [10] (Additional file 1: Table S1). c Kaplan Meier analysis of categorized (high/low) mRNA levels of i) CD44; ii) RHAMM and iii) AGL and RHAMM and overall survival in the Kim et al. [10] bladder patient dataset. Hazard Ratios (HR) and logrank P values are shown. High- and low-expression groups were determined by an optimal cutoff that gave the best p-value and was selected from nine different percentiles (from 10th to 90th). The optimal cutoff was 20th percentile for CD44, 60th percentile for RHAMM and 30th percentile for AGL

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