Skip to main content

Table 5 Multivariate Cox regression analysis of survival, stratified by stage at diagnosis

From: Racial differences in six major subtypes of melanoma: descriptive epidemiology

 

In situ

Localized

Regional

Distant

HR

95 % CI

P

HR

95 % CI

P

HR

95 % CI

P

HR

95 % CI

P

Melanoma in situ

 Gender

   

-

-

-

-

-

-

-

-

-

  Male

1

  

-

-

-

-

-

-

-

-

-

  Female

0.502

0.398–0.634

0.000

-

-

-

-

-

-

-

-

-

 Age at diagnosis

1.098

1.087–1.110

0.000

-

-

-

-

-

-

-

-

-

 Marital Status

   

-

-

-

-

-

-

-

-

-

  Single

1

  

-

-

-

-

-

-

-

-

-

  Married

0.770

0.539–1.099

0.150

-

-

-

-

-

-

-

-

-

  Separated/divorced/widowed

1.225

0.831–1.806

0.305

-

-

-

-

-

-

-

-

-

 Ethnic group

   

-

-

-

-

-

-

-

-

-

  NHW

1

  

-

-

-

-

-

-

-

-

-

  HW

1.886

0.888–4.006

0.099

-

-

-

-

-

-

-

-

-

  Black

0.709

0.098–5.115

0.733

-

-

-

-

-

-

-

-

-

  Asian/PI

0.624

0.087–4.495

0.640

-

-

-

-

-

-

-

-

-

 Anatomic Site

   

-

-

-

-

-

-

-

-

-

  Face/head/neck

1

  

-

-

-

-

-

-

-

-

-

  Trunk

0.993

0.783–1.259

0.952

-

-

-

-

-

-

-

-

-

  Upper Extremity

0.876

0.668–1.149

0.338

-

-

-

-

-

-

-

-

-

  Lower Extremity

0.753

0.500–1.133

0.174

-

-

-

-

-

-

-

-

-

  Other

1.081

0.399–2.929

0.878

-

-

-

-

-

-

-

-

-

 Treatment

   

-

-

-

-

-

-

-

-

-

  No surgery or radiation

1

  

-

-

-

-

-

-

-

-

-

  Surgery

1.125

0.531–2.387

0.758

-

-

-

-

-

-

-

-

-

  Radiation

0.185

--

0.989

-

-

-

-

-

-

-

-

-

  Radiation & Surgery

1.041

0.214–5.063

0.961

-

-

-

-

-

-

-

-

-

 Thickness of tumor (mm)

1.043

0.993–1.095

0.091

-

-

-

-

-

-

-

-

-

 Ulceration

   

-

-

-

-

-

-

-

-

-

  No

1

  

-

-

-

-

-

-

-

-

-

  Yes

1.722

0.847–3.503

0.133

-

-

-

-

-

-

-

-

-

Superficial spreading melanoma

 Gender

            

  Male

-

-

-

1

  

1

  

1

  

  Female

-

-

-

0.709

0.677–0.742

0.000

0.718

0.644–0.801

0.000

0.657

0.452–0.955

0.028

 Age at diagnosis

-

-

-

1.074

1.072–1.075

0.000

1.033

1.029–1.036

0.000

1.018

1.007–1.029

0.001

 Marital Status

            

  Single

-

-

-

1

  

1

  

1

  

  Married

-

-

-

0.741

0.693–0.792

0.000

0.724

0.631–0.832

0.000

0.505

0.337–0.757

0.001

  Separated/divorced/widowed

-

-

-

1.034

0.957–1.117

0.400

0.897

0.759–1.059

0.199

0.791

0.480–1.301

0.355

 Ethnic group

            

  NHW

-

-

-

1

  

1

  

1

  

  HW

-

-

-

1.065

0.915–1.241

0.416

1.213

0.909–1.620

0.190

0.931

0.468–1.850

0.837

  Black

-

-

-

0.920

0.605–1.398

0.696

0.954

0.549–1.657

0.867

1.171

0.156–8.812

0.878

  Asian/PI

-

-

-

1.008

0.726–1.398

0.964

1.028

0.606–1.745

0.918

0.821

0.196–3.447

0.788

 Anatomic Site

            

  Face/head/neck

-

-

-

1

  

1

  

1

  

  Trunk

-

-

-

0.849

0.804–0.896

0.000

0.896

0.788–1.020

0.098

1.570

1.062–2.319

0.024

  Upper Extremity

-

-

-

0.750

0.707–0.795

0.000

0.800

0.692–0.925

0.003

1.606

1.034–2.493

0.035

  Lower Extremity

-

-

-

0.655

0.611–0.701

0.000

0.820

0.707–0.951

0.009

1.384

0.825–2.323

0.218

  Other

-

-

-

1.031

0.731–1.455

0.860

1.359

0.507–3.646

0.542

0.000

--

0.954

 Treatment

            

  No surgery or radiation

-

-

-

1

  

1

  

1

  

  Surgery

-

-

-

0.584

0.468–0.729

0.000

2.030

0.652–6.316

0.222

0.274

0.116–0.645

0.003

  Radiation

-

-

-

1.738

0.427–7.077

0.440

5.760

0.597–55.57

0.130

1.454

0.397–5.328

0.572

  Radiation & Surgery

-

-

-

1.175

0.841–1.640

0.345

4.154

1.316–13.11

0.015

0.750

0.306–1.836

0.529

 Thickness of tumor (mm)

-

-

-

1.223

1.207–1.239

0.000

1.152

1.128–1.176

0.000

1.107

1.043–1.175

0.001

 Ulceration

            

  No

-

-

-

1

  

1

  

1

  

  Yes

-

-

-

1.355

1.226–1.498

0.000

1.082

0.984–1.190

0.102

1.011

0.703–1.453

0.954

Nodular melanoma

 Gender

  Male

-

-

-

1

  

1

  

1

  

  Female

-

-

-

0.753

0.698–0.812

0.000

0.790

0.728–0.858

0.000

1.069

0.879–1.299

0.504

 Age at diagnosis

-

-

-

1.048

1.045–1.050

0.000

1.028

1.026–1.031

0.000

1.010

1.004–1.015

0.001

 Marital Status

  Single

-

-

-

1

  

1

  

1

  

  Married

-

-

-

0.707

0.636–0.785

0.000

0.799

0.722–0.885

0.000

0.763

0.600–0.970

0.027

  Separated/divorced/widowed

-

-

-

0.944

0.838–1.063

0.341

1.001

0.887–1.129

0.987

0.880

0.663–1.167

0.374

 Ethnic group

  NHW

-

-

-

1

  

1

  

1

  

  HW

-

-

-

0.924

0.739–1.155

0.486

1.150

0.958–1.380

0.134

0.625

0.416–0.940

0.024

  Black

-

-

-

1.533

0.887–2.647

0.126

1.335

0.876–2.035

0.179

0.597

0.243–1.467

0.261

  Asian/PI

-

-

-

0.938

0.597–1.475

0.783

0.781

0.540–1.128

0.187

0.959

0.469–1.961

0.910

 Anatomic Site

  Face/head/neck

-

-

-

1

  

1

  

1

  

  Trunk

-

-

-

1.046

0.957–1.143

0.320

1.125

1.023–1.238

0.016

1.284

1.027–1.605

0.029

  Upper Extremity

-

-

-

0.846

0.773–0.926

0.000

0.901

0.813–0.998

0.046

0.960

0.745–1.237

0.750

  Lower Extremity

-

-

-

0.832

0.743–0.931

0.001

0.984

0.879–1.101

0.775

0.936

0.711–1.232

0.636

  Other

-

-

-

0.974

0.572–1.660

0.923

0.940

0.518–1.705

0.838

3.880

0.942–15.986

0.061

 Treatment

  No surgery or radiation

-

-

-

1

  

1

  

1

  

  Surgery

-

-

-

0.498

0.358–0.692

0.000

0.416

0.276–0.628

0.000

0.459

0.282–0.748

0.002

  Radiation

-

-

-

1.813

0.644–5.102

0.260

0.418

0.056–3.102

0.394

0.626

0.210–1.866

0.400

  Radiation & Surgery

-

-

-

1.012

0.667–1.536

1.012

0.648

0.419–1.003

0.051

0.678

0.409–1.124

0.132

 Thickness of tumor (mm)

-

-

-

1.120

1.104–1.136

0.000

1.074

1.060–1.088

0.000

1.017

0.989–1.044

0.235

 Ulceration

  No

-

-

-

1

  

1

  

1

  

  Yes

-

-

-

1.215

1.116–1.323

0.000

1.074

1.000–1.155

0.051

0.834

0.699–0.997

0.046

Lentigo maligna melanoma

 Gender

  Male

-

-

-

1

  

1

  

1

  

  Female

-

-

-

0.641

0.589–0.698

0.000

0.641

0.471–0.872

0.005

1.968

0.468–8.271

0.355

 Age at diagnosis

-

-

-

1.093

1.088–1.097

0.000

1.050

1.036–1.065

0.000

1.016

0.965–1.070

0.550

 Marital Status

  Single

-

-

-

1

  

1

  

1

  

  Married

-

-

-

0.758

0.660–0.870

0.000

0.858

0.508–1.449

0.566

1.701

0.345–8.396

0.514

  Separated/divorced/widowed

-

-

-

0.939

0.808–1.091

0.409

1.137

0.657–1.969

0.646

0.744

0.082–6.771

0.793

 Ethnic group

  NHW

-

-

-

1

  

1

  

1

  

  HW

-

-

-

0.981

0.723–1.330

0.900

0.619

0.196–1.954

0.414

-

-

-

  Black

-

-

-

1.029

0.486–2.180

0.940

9.996

1.239–80.642

0.031

0.308

0.009–10.073

0.508

  Asian

-

-

-

0.587

0.244–1.412

0.234

1.120

0.331–3.793

0.855

-

-

-

 Anatomic Site

  Face/head/neck

-

-

-

1

  

1

  

1

  

  Trunk

-

-

-

0.909

0.812–1.018

0.099

1.068

0.666–1.713

0.785

5.787

1.173-28.562

0.031

  Upper Extremity

-

-

-

0.888

0.806–0.978

0.016

0.988

0.656–1.488

0.954

1.564

0.145–16.844

0.712

  Lower Extremity

-

-

-

0.802

0.655–0.981

0.032

0.670

0.363–1.234

0.198

-

-

-

  Other

-

-

-

1.218

0.792–1.873

0.369

-

-

-

-

-

-

 Treatment

  No surgery or radiation

-

-

-

1

  

1

  

-

-

-

  Surgery

-

-

-

0.734

0.530–1.015

0.062

1.768

0.245–12.759

0.572

1

  

  Radiation

-

-

-

0.017

--

0.902

-

-

-

135.011

--

0.000

  Radiation & Surgery

-

-

-

1.202

0.703–2.056

0.501

3.478

0.445–27.195

0.235

7.513

1.689–33.427

0.008

 Thickness of tumor (mm)

-

-

-

1.130

1.098–1.162

0.000

1.094

1.030–1.161

0.003

1.142

0.893–1.460

0.289

 Ulceration

  No

-

-

-

1

  

1

  

1

  

  Yes

-

-

-

1.243

0.971–1.592

0.085

1.242

0.949–1.626

0.114

2.834

0.458–17.545

0.263

Acral lentiginous melanoma, malignant

 Gender

  Male

-

-

-

1

  

1

  

1

  

  Female

-

-

-

0.810

0.649–1.011

0.062

0.595

0.471–0.752

0.000

0.828

0.449–1.529

0.546

Age at diagnosis

-

-

-

1.069

1.059–1.079

0.000

1.025

1.017–1.034

0.000

1.040

1.013–1.067

0.003

 Marital Status

  Single

-

-

-

1

  

1

  

1

  

  Married

-

-

-

0.922

0.638–1.332

0.665

0.790

0.550–1.136

0.204

0.340

0.120–0.967

0.043

  Separated/divorced/widowed

-

-

-

1.063

0.719–1.572

0.761

1.093

0.744–1.606

0.652

0.337

0.099–1.147

0.082

 Ethnic group

  Non-Hispanic white

-

-

-

1

  

1

  

1

  

  Hispanic white

-

-

-

0.771

0.530–1.123

0.176

1.219

0.884–1.682

0.228

0.987

0.409–2.381

0.977

  Black

-

-

-

1.112

0.803–1.540

0.523

1.080

0.751–1.553

0.678

0.601

0.254–1.420

0.246

  Asian

-

-

-

1.307

0.826–2.068

0.254

0.843

0.568–1.250

0.396

0.630

0.183–2.176

0.465

 Anatomic Site

  Face/head/neck

-

-

-

1

  

1

  

-

-

-

  Trunk

-

-

-

0.845

0.280–2.552

0.765

0.770

0.123–4.845

0.781

1

  

  Upper Extremity

-

-

-

0.978

0.447–2.140

0.956

0.933

0.275–3.162

0.912

0.253

0.045–1.403

0.116

  Lower Extremity

-

-

-

1.004

0.472–2.139

0.991

1.277

0.383–4.250

0.691

0.302

0.060–1.509

0.145

  Other

-

-

-

0.913

0.111–7.533

0.933

0.011

--

0.962

-

-

-

 Treatment

  No surgery or radiation

-

-

-

1

  

1

  

1

  

  Surgery

-

-

-

0.372

0.162–0.855

0.020

0.065

0.020–0.213

0.000

0.150

0.031–0.718

0.018

  Radiation

-

-

-

0.431

0.049–3.766

0.446

-

-

-

0.946

0.112–7.994

0.959

  Radiation & Surgery

-

-

-

0.151

0.018–1.271

0.082

0.179

0.047–0.687

0.012

0.528

0.091–3.061

0.476

Thickness of tumor (mm)

-

-

-

1.137

1.072–1.206

0.000

1.115

1.069–1.163

0.000

1.094

0.988–1.211

0.083

 Ulceration

  No

-

-

-

1

  

1

  

1

  

  Yes

-

-

-

1.544

1.112–2.143

0.009

1.103

0.888–1.368

0.376

2.281

1.216–4.280

0.010

Malignant melanoma, NOS

 Gender

  Male

-

-

-

1

  

1

  

1

  

  Female

-

-

-

0.705

0.676–0.735

0.000

0.800

0.742–0.862

0.000

0.881

0.752–1.032

0.117

 Age at diagnosis

-

-

-

1.069

1.068–1.071

0.000

1.033

1.031–1.035

0.000

1.014

1.010–1.019

0.000

 Marital Status

  Single

-

-

-

1

  

1

  

1

  

  Married

-

-

-

0.731

0.690–0.776

0.000

0.777

0.704–0.857

0.000

0.630

0.521–0.762

0.000

  Separated/divorced/widowed

-

-

-

0.985

0.921–1.054

0.660

0.993

0.886–1.114

0.910

0.848

0.673–1.069

0.163

 Ethnic group

  NHW

-

-

-

1

  

1

  

1

  

  HW

-

-

-

1.134

1.002–1.284

0.046

1.240

1.056–1.455

0.009

0.970

0.704–1.336

0.852

  Black

-

-

-

1.389

1.086–1.777

0.009

1.372

1.056–1.782

0.018

0.859

0.516–1.431

0.561

  Asian/PI

-

-

-

1.004

0.782–1.290

0.973

1.052

0.772–1.434

0.748

1.478

0.850–2.571

0.167

 Anatomic Site

  Face/head/neck

-

-

-

1

  

1

  

1

  

  Trunk

-

-

-

0.918

0.876–0.962

0.000

1.087

0.994–1.189

0.068

1.098

0.913–1.320

0.320

  Upper Extremity

-

-

-

0.811

0.772–0.852

0.000

0.859

0.779–0.948

0.003

0.970

0.782–1.203

0.778

  Lower Extremity

-

-

-

0.732

0.687–0.779

0.000

0.910

0.823–1.006

0.065

0.835

0.672–1.037

0.103

  Other

-

-

-

0.911

0.690–1.201

0.506

1.416

0.908–2.208

0.125

1.011

0.631–1.619

0.964

 Treatment

  No surgery or radiation

-

-

-

1

  

1

  

1

  

  Surgery

-

-

-

0.656

0.572–0.752

0.000

0.392

0.291–0.530

0.000

0.472

0.357–0.626

0.000

  Radiation

-

-

-

2.551

1.424–4.570

0.002

1.886

0.886–4.016

0.100

1.647

1.033–2.625

0.036

  Radiation & Surgery

-

-

-

1.312

1.069–1.610

0.009

0.732

0.531–1.011

0.058

0.747

0.549–1.016

0.063

 Thickness of tumor (mm)

-

-

-

1.196

1.183–1.208

0.000

1.086

1.073–1.099

0.000

1.045

1.021–1.069

0.000

 Ulceration

  No

-

-

-

1

  

1

  

1

  

  Yes

-

-

-

1.448

1.351–1.553

0.000

1.172

1.097–1.252

0.000

1.002

0.858–1.172

0.975

  1. Cancers diagnosed 1973–2006 and followed up to 12/31/2011
  2. HR hazard ratio
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us