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Table 5 Multivariate Cox regression analysis of survival, stratified by stage at diagnosis

From: Racial differences in six major subtypes of melanoma: descriptive epidemiology

  In situ Localized Regional Distant
HR 95 % CI P HR 95 % CI P HR 95 % CI P HR 95 % CI P
Melanoma in situ
 Gender     - - - - - - - - -
  Male 1    - - - - - - - - -
  Female 0.502 0.398–0.634 0.000 - - - - - - - - -
 Age at diagnosis 1.098 1.087–1.110 0.000 - - - - - - - - -
 Marital Status     - - - - - - - - -
  Single 1    - - - - - - - - -
  Married 0.770 0.539–1.099 0.150 - - - - - - - - -
  Separated/divorced/widowed 1.225 0.831–1.806 0.305 - - - - - - - - -
 Ethnic group     - - - - - - - - -
  NHW 1    - - - - - - - - -
  HW 1.886 0.888–4.006 0.099 - - - - - - - - -
  Black 0.709 0.098–5.115 0.733 - - - - - - - - -
  Asian/PI 0.624 0.087–4.495 0.640 - - - - - - - - -
 Anatomic Site     - - - - - - - - -
  Face/head/neck 1    - - - - - - - - -
  Trunk 0.993 0.783–1.259 0.952 - - - - - - - - -
  Upper Extremity 0.876 0.668–1.149 0.338 - - - - - - - - -
  Lower Extremity 0.753 0.500–1.133 0.174 - - - - - - - - -
  Other 1.081 0.399–2.929 0.878 - - - - - - - - -
 Treatment     - - - - - - - - -
  No surgery or radiation 1    - - - - - - - - -
  Surgery 1.125 0.531–2.387 0.758 - - - - - - - - -
  Radiation 0.185 -- 0.989 - - - - - - - - -
  Radiation & Surgery 1.041 0.214–5.063 0.961 - - - - - - - - -
 Thickness of tumor (mm) 1.043 0.993–1.095 0.091 - - - - - - - - -
 Ulceration     - - - - - - - - -
  No 1    - - - - - - - - -
  Yes 1.722 0.847–3.503 0.133 - - - - - - - - -
Superficial spreading melanoma
 Gender             
  Male - - - 1    1    1   
  Female - - - 0.709 0.677–0.742 0.000 0.718 0.644–0.801 0.000 0.657 0.452–0.955 0.028
 Age at diagnosis - - - 1.074 1.072–1.075 0.000 1.033 1.029–1.036 0.000 1.018 1.007–1.029 0.001
 Marital Status             
  Single - - - 1    1    1   
  Married - - - 0.741 0.693–0.792 0.000 0.724 0.631–0.832 0.000 0.505 0.337–0.757 0.001
  Separated/divorced/widowed - - - 1.034 0.957–1.117 0.400 0.897 0.759–1.059 0.199 0.791 0.480–1.301 0.355
 Ethnic group             
  NHW - - - 1    1    1   
  HW - - - 1.065 0.915–1.241 0.416 1.213 0.909–1.620 0.190 0.931 0.468–1.850 0.837
  Black - - - 0.920 0.605–1.398 0.696 0.954 0.549–1.657 0.867 1.171 0.156–8.812 0.878
  Asian/PI - - - 1.008 0.726–1.398 0.964 1.028 0.606–1.745 0.918 0.821 0.196–3.447 0.788
 Anatomic Site             
  Face/head/neck - - - 1    1    1   
  Trunk - - - 0.849 0.804–0.896 0.000 0.896 0.788–1.020 0.098 1.570 1.062–2.319 0.024
  Upper Extremity - - - 0.750 0.707–0.795 0.000 0.800 0.692–0.925 0.003 1.606 1.034–2.493 0.035
  Lower Extremity - - - 0.655 0.611–0.701 0.000 0.820 0.707–0.951 0.009 1.384 0.825–2.323 0.218
  Other - - - 1.031 0.731–1.455 0.860 1.359 0.507–3.646 0.542 0.000 -- 0.954
 Treatment             
  No surgery or radiation - - - 1    1    1   
  Surgery - - - 0.584 0.468–0.729 0.000 2.030 0.652–6.316 0.222 0.274 0.116–0.645 0.003
  Radiation - - - 1.738 0.427–7.077 0.440 5.760 0.597–55.57 0.130 1.454 0.397–5.328 0.572
  Radiation & Surgery - - - 1.175 0.841–1.640 0.345 4.154 1.316–13.11 0.015 0.750 0.306–1.836 0.529
 Thickness of tumor (mm) - - - 1.223 1.207–1.239 0.000 1.152 1.128–1.176 0.000 1.107 1.043–1.175 0.001
 Ulceration             
  No - - - 1    1    1   
  Yes - - - 1.355 1.226–1.498 0.000 1.082 0.984–1.190 0.102 1.011 0.703–1.453 0.954
Nodular melanoma
 Gender
  Male - - - 1    1    1   
  Female - - - 0.753 0.698–0.812 0.000 0.790 0.728–0.858 0.000 1.069 0.879–1.299 0.504
 Age at diagnosis - - - 1.048 1.045–1.050 0.000 1.028 1.026–1.031 0.000 1.010 1.004–1.015 0.001
 Marital Status
  Single - - - 1    1    1   
  Married - - - 0.707 0.636–0.785 0.000 0.799 0.722–0.885 0.000 0.763 0.600–0.970 0.027
  Separated/divorced/widowed - - - 0.944 0.838–1.063 0.341 1.001 0.887–1.129 0.987 0.880 0.663–1.167 0.374
 Ethnic group
  NHW - - - 1    1    1   
  HW - - - 0.924 0.739–1.155 0.486 1.150 0.958–1.380 0.134 0.625 0.416–0.940 0.024
  Black - - - 1.533 0.887–2.647 0.126 1.335 0.876–2.035 0.179 0.597 0.243–1.467 0.261
  Asian/PI - - - 0.938 0.597–1.475 0.783 0.781 0.540–1.128 0.187 0.959 0.469–1.961 0.910
 Anatomic Site
  Face/head/neck - - - 1    1    1   
  Trunk - - - 1.046 0.957–1.143 0.320 1.125 1.023–1.238 0.016 1.284 1.027–1.605 0.029
  Upper Extremity - - - 0.846 0.773–0.926 0.000 0.901 0.813–0.998 0.046 0.960 0.745–1.237 0.750
  Lower Extremity - - - 0.832 0.743–0.931 0.001 0.984 0.879–1.101 0.775 0.936 0.711–1.232 0.636
  Other - - - 0.974 0.572–1.660 0.923 0.940 0.518–1.705 0.838 3.880 0.942–15.986 0.061
 Treatment
  No surgery or radiation - - - 1    1    1   
  Surgery - - - 0.498 0.358–0.692 0.000 0.416 0.276–0.628 0.000 0.459 0.282–0.748 0.002
  Radiation - - - 1.813 0.644–5.102 0.260 0.418 0.056–3.102 0.394 0.626 0.210–1.866 0.400
  Radiation & Surgery - - - 1.012 0.667–1.536 1.012 0.648 0.419–1.003 0.051 0.678 0.409–1.124 0.132
 Thickness of tumor (mm) - - - 1.120 1.104–1.136 0.000 1.074 1.060–1.088 0.000 1.017 0.989–1.044 0.235
 Ulceration
  No - - - 1    1    1   
  Yes - - - 1.215 1.116–1.323 0.000 1.074 1.000–1.155 0.051 0.834 0.699–0.997 0.046
Lentigo maligna melanoma
 Gender
  Male - - - 1    1    1   
  Female - - - 0.641 0.589–0.698 0.000 0.641 0.471–0.872 0.005 1.968 0.468–8.271 0.355
 Age at diagnosis - - - 1.093 1.088–1.097 0.000 1.050 1.036–1.065 0.000 1.016 0.965–1.070 0.550
 Marital Status
  Single - - - 1    1    1   
  Married - - - 0.758 0.660–0.870 0.000 0.858 0.508–1.449 0.566 1.701 0.345–8.396 0.514
  Separated/divorced/widowed - - - 0.939 0.808–1.091 0.409 1.137 0.657–1.969 0.646 0.744 0.082–6.771 0.793
 Ethnic group
  NHW - - - 1    1    1   
  HW - - - 0.981 0.723–1.330 0.900 0.619 0.196–1.954 0.414 - - -
  Black - - - 1.029 0.486–2.180 0.940 9.996 1.239–80.642 0.031 0.308 0.009–10.073 0.508
  Asian - - - 0.587 0.244–1.412 0.234 1.120 0.331–3.793 0.855 - - -
 Anatomic Site
  Face/head/neck - - - 1    1    1   
  Trunk - - - 0.909 0.812–1.018 0.099 1.068 0.666–1.713 0.785 5.787 1.173-28.562 0.031
  Upper Extremity - - - 0.888 0.806–0.978 0.016 0.988 0.656–1.488 0.954 1.564 0.145–16.844 0.712
  Lower Extremity - - - 0.802 0.655–0.981 0.032 0.670 0.363–1.234 0.198 - - -
  Other - - - 1.218 0.792–1.873 0.369 - - - - - -
 Treatment
  No surgery or radiation - - - 1    1    - - -
  Surgery - - - 0.734 0.530–1.015 0.062 1.768 0.245–12.759 0.572 1   
  Radiation - - - 0.017 -- 0.902 - - - 135.011 -- 0.000
  Radiation & Surgery - - - 1.202 0.703–2.056 0.501 3.478 0.445–27.195 0.235 7.513 1.689–33.427 0.008
 Thickness of tumor (mm) - - - 1.130 1.098–1.162 0.000 1.094 1.030–1.161 0.003 1.142 0.893–1.460 0.289
 Ulceration
  No - - - 1    1    1   
  Yes - - - 1.243 0.971–1.592 0.085 1.242 0.949–1.626 0.114 2.834 0.458–17.545 0.263
Acral lentiginous melanoma, malignant
 Gender
  Male - - - 1    1    1   
  Female - - - 0.810 0.649–1.011 0.062 0.595 0.471–0.752 0.000 0.828 0.449–1.529 0.546
Age at diagnosis - - - 1.069 1.059–1.079 0.000 1.025 1.017–1.034 0.000 1.040 1.013–1.067 0.003
 Marital Status
  Single - - - 1    1    1   
  Married - - - 0.922 0.638–1.332 0.665 0.790 0.550–1.136 0.204 0.340 0.120–0.967 0.043
  Separated/divorced/widowed - - - 1.063 0.719–1.572 0.761 1.093 0.744–1.606 0.652 0.337 0.099–1.147 0.082
 Ethnic group
  Non-Hispanic white - - - 1    1    1   
  Hispanic white - - - 0.771 0.530–1.123 0.176 1.219 0.884–1.682 0.228 0.987 0.409–2.381 0.977
  Black - - - 1.112 0.803–1.540 0.523 1.080 0.751–1.553 0.678 0.601 0.254–1.420 0.246
  Asian - - - 1.307 0.826–2.068 0.254 0.843 0.568–1.250 0.396 0.630 0.183–2.176 0.465
 Anatomic Site
  Face/head/neck - - - 1    1    - - -
  Trunk - - - 0.845 0.280–2.552 0.765 0.770 0.123–4.845 0.781 1   
  Upper Extremity - - - 0.978 0.447–2.140 0.956 0.933 0.275–3.162 0.912 0.253 0.045–1.403 0.116
  Lower Extremity - - - 1.004 0.472–2.139 0.991 1.277 0.383–4.250 0.691 0.302 0.060–1.509 0.145
  Other - - - 0.913 0.111–7.533 0.933 0.011 -- 0.962 - - -
 Treatment
  No surgery or radiation - - - 1    1    1   
  Surgery - - - 0.372 0.162–0.855 0.020 0.065 0.020–0.213 0.000 0.150 0.031–0.718 0.018
  Radiation - - - 0.431 0.049–3.766 0.446 - - - 0.946 0.112–7.994 0.959
  Radiation & Surgery - - - 0.151 0.018–1.271 0.082 0.179 0.047–0.687 0.012 0.528 0.091–3.061 0.476
Thickness of tumor (mm) - - - 1.137 1.072–1.206 0.000 1.115 1.069–1.163 0.000 1.094 0.988–1.211 0.083
 Ulceration
  No - - - 1    1    1   
  Yes - - - 1.544 1.112–2.143 0.009 1.103 0.888–1.368 0.376 2.281 1.216–4.280 0.010
Malignant melanoma, NOS
 Gender
  Male - - - 1    1    1   
  Female - - - 0.705 0.676–0.735 0.000 0.800 0.742–0.862 0.000 0.881 0.752–1.032 0.117
 Age at diagnosis - - - 1.069 1.068–1.071 0.000 1.033 1.031–1.035 0.000 1.014 1.010–1.019 0.000
 Marital Status
  Single - - - 1    1    1   
  Married - - - 0.731 0.690–0.776 0.000 0.777 0.704–0.857 0.000 0.630 0.521–0.762 0.000
  Separated/divorced/widowed - - - 0.985 0.921–1.054 0.660 0.993 0.886–1.114 0.910 0.848 0.673–1.069 0.163
 Ethnic group
  NHW - - - 1    1    1   
  HW - - - 1.134 1.002–1.284 0.046 1.240 1.056–1.455 0.009 0.970 0.704–1.336 0.852
  Black - - - 1.389 1.086–1.777 0.009 1.372 1.056–1.782 0.018 0.859 0.516–1.431 0.561
  Asian/PI - - - 1.004 0.782–1.290 0.973 1.052 0.772–1.434 0.748 1.478 0.850–2.571 0.167
 Anatomic Site
  Face/head/neck - - - 1    1    1   
  Trunk - - - 0.918 0.876–0.962 0.000 1.087 0.994–1.189 0.068 1.098 0.913–1.320 0.320
  Upper Extremity - - - 0.811 0.772–0.852 0.000 0.859 0.779–0.948 0.003 0.970 0.782–1.203 0.778
  Lower Extremity - - - 0.732 0.687–0.779 0.000 0.910 0.823–1.006 0.065 0.835 0.672–1.037 0.103
  Other - - - 0.911 0.690–1.201 0.506 1.416 0.908–2.208 0.125 1.011 0.631–1.619 0.964
 Treatment
  No surgery or radiation - - - 1    1    1   
  Surgery - - - 0.656 0.572–0.752 0.000 0.392 0.291–0.530 0.000 0.472 0.357–0.626 0.000
  Radiation - - - 2.551 1.424–4.570 0.002 1.886 0.886–4.016 0.100 1.647 1.033–2.625 0.036
  Radiation & Surgery - - - 1.312 1.069–1.610 0.009 0.732 0.531–1.011 0.058 0.747 0.549–1.016 0.063
 Thickness of tumor (mm) - - - 1.196 1.183–1.208 0.000 1.086 1.073–1.099 0.000 1.045 1.021–1.069 0.000
 Ulceration
  No - - - 1    1    1   
  Yes - - - 1.448 1.351–1.553 0.000 1.172 1.097–1.252 0.000 1.002 0.858–1.172 0.975
  1. Cancers diagnosed 1973–2006 and followed up to 12/31/2011
  2. HR hazard ratio