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Table 1 Patients’ characteristics and clinicopathologic features

From: Racial differences in six major subtypes of melanoma: descriptive epidemiology

  Melanoma in situ Superficial spreading melanoma Nodular melanoma
NHW (n = 87852) HW (n = 1890) Black (n = 222) Asian/PI (n = 180) P NHW (n = 84790) HW (n = 1993) Black (n = 218) Asian/PI (n = 364) P NHW (n = 19260) HW (n = 689) Black (n = 106) Asian/PI (n = 160) P
Gender      <0.001      <0.001      <0.001
 Male 54.7 36.0 45.0 44.6   53.3 35.6 42.2 49.2   61.6 51.8 44.3 56.3  
 Female 45.3 64.0 55.0 55.4   46.7 64.4 57.8 50.8   38.4 48.2 55.7 43.8  
Marital Status      <0.001      <0.001      <0.001
 Single 12.6 15.4 22.1 18.8   15.4 18.8 26.3 23.9   14.9 21.3 37.0 17.6  
 Married 73.9 70.8 54.7 67.7   71.2 67.7 48.1 62.7   63.5 58.5 34.8 62.0  
 Separated/divorced/widowed 13.5 13.8 23.3 13.5   13.4 13.5 25.6 13.4   21.6 20.2 28.3 20.4  
Age at diagnosis 60.5 ± 15.9 55.6 ± 16.9 59.2 ± 16.2 55.0 ± 17.9 <0.001 54.7 ± 16.7 49.2 ± 16.5 56.0 ± 17.7 52.7 ± 17.3 <0.001 62.1 ± 17.7 55.9 ± 19.1 62.7 ± 18.1 60.3 ± 20.1 <0.001
Anatomic Site      <0.001      <0.001      <0.001
 Face/head/neck 25.7 28.6 18.0 22.3   13.7 14.4 9.6 11.0   22.9 22.5 15.1 16.9  
 Trunk 30.9 24.1 12.6 26.0   39.0 33.9 29.8 36.0   32.1 28.3 18.9 26.3  
 Upper Extremity 25.9 23.9 24.8 22.8   25.7 22.9 17.0 18.7   27.1 20.8 12.3 13.8  
 Lower Extremity 17.0 23.0 44.1 29.0   21.0 28.4 42.2 33.5   17.4 28.0 51.9 43.1  
 Other 0.6 0.5 0.5 0   0.5 0.4 1.4 0.8   0.6 0.4 1.9 0  
Thickness of tumor (mm) 0.80 ± 1.83 0.78 ± 1.85 1.02 ± 1.31 0.68 ± 0.88 0.980 0.92 ± 1.09 1.01 ± 1.20 1.51 ± 2.11 1.36 ± 1.96 <0.001 3.27 ± 2.51 3.93 ± 3.02 4.22 ± 3.18 4.23 ± 3.04 <0.001
Satellite nodules           0.012      0.280
 No - - - -   97.0 97.2 95.9 95.3   93.5 93.9 88.7 95.6  
 Yes - - - -   0.6 1.1 0.9 0.8   3.6 3.5 4.7 3.1  
 Unknown - - - -   2.4 1.7 3.2 3.8   3.0 2.6 6.6 1.3  
Ulceration      0.242      0.001      0.001
 No 92.2 91.7 94.1 91.1   86.7 87.6 83.5 87.4   59.8 56.0 50.9 56.3  
 Yes 0.5 0.4 0.9 0   4.9 6.0 8.3 6.6   31.4 38.3 37.7 35.6  
 Unknown 7.3 7.9 5.0 8.9   8.4 6.4 8.3 6.0   8.8 5.7 11.3 8.1  
Lymph node extension      0.866      <0.001      <0.001
 None 99.9 99.8 99.5 100.0   72.7 78.8 67.0 76.9   63.3 60.4 52.8 58.1  
 Regional 0 0 0 0   3.2 4.7 5.0 6.6   16.6 25.3 18.9 25.0  
 Distant 0 0 0 0   0.1 0.2 0 0   0.9 2.0 5.7 1.9  
 Unknown 0.1 0.2 0.5 0   24.0 16.3 28.0 16.5   19.2 12.3 22.6 15.0  
Stage      0.996      <0.001      <0.001
 In situ 100.0 100.0 100.0 100.0   - - - -   - - - -  
 Localized - - - -   92.7 90.8 86.7 87.9   62.1 51.1 43.4 52.5  
 Regional - - - -   5.4 7.4 9.6 9.6   32.0 40.1 38.7 41.3  
 Distant - - - -   0.4 0.8 0.9 0.8   4.1 7.1 14.2 5.6  
 Unstaged 0.0 - - -   1.5 1.1 2.8 1.6   1.9 1.7 3.8 0.6  
Treatment      0.152      0.005      0.033
 No treatment 4.1 5.8 5.0 4.2   1.6 2.0 1.4 2.2   1.5 1.6 1.9 1.3  
 Surgery 95.1 93.7 94.6 95.3   97.1 97.1 95.4 95.6   94.7 94.8 90.6 93.8  
 Radiation 0.1 0.1 0 0.2   0.1 0 0.5 0   0.2 0 0 1.3  
 Radiation & Surgery 0.4 0.3 0 0   0.9 0.8 1.4 1.9   3.3 3.2 5.7 3.1  
 Unknown 0.2 0.2 0.5 0.2   0.4 0.1 1.4 0.3   0.4 0.4 1.9 0.6  
Type of surgery      <0.001      <0.001      <0.001
 No surgery 4.2 5.9 5.1 4.5   1.7 2.1 1.6 2.3   1.8 1.7 2.0 2.1  
 Biopsy 65.8 63.9 51.6 55.8   43.0 43.6 37.0 42.9   32.5 35.1 34.3 32.9  
 Wide excision 29.8 29.9 40.0 39.3   55.0 53.5 59.3 54.2   64.3 57.3 57.6 60.3  
 Amputation 0.1 0.2 2.8 0.5   0.1 0.4 2.1 0.3   0.5 3.5 3.0 4.1  
 Surgery NOS 0.1 0.1 0.5 0   0.3 0.5 0 0.3   0.9 2.4 3.0 0.7  
Survival time (month) 300.7 ± 3.0 355.9 ± 13.1 287.8 ± 15.3 325.6 ± 19.6 <0.001 298.7 ± 1.2 305.8 ± 6.3 277.1 ± 17.5 300.2 ± 13.6 0.001 168.5 ± 1.8 160.3 ± 9.6 106.9 ± 14.3 145.8 ± 16.6 0.033
  Lentigo maligna melanoma Acral lentiginous melanoma, malignant Malignant melanoma, NOS
NHW (n = 17226) HW (n = 250) Black (n = 46) Asian/PI (n = 69) P NHW (n = 1822) HW (n = 300) Black (n = 215) Asian/PI (n = 168) P NHW (n = 127924) HW (n = 3807) Black (n = 788) Asian/PI (n = 861) P
Gender      <0.001      0.138      <0.001
 Male 67.2 54.4 54.3 56.5   46.5 46.3 40.9 53.0   57.5 42.6 48.4 48.5  
 Female 32.8 45.6 45.7 43.5   53.5 53.7 59.1 47.0   42.5 57.4 51.6 51.5  
Marital Status      0.283      <0.001      <0.001
 Single 8.3 11.6 6.3 7.4   12.9 15.2 17.3 10.2   14.8 20.5 28.0 16.2  
 Married 71.4 71.1 59.4 74.1   65.7 59.8 42.6 67.5   68.8 63.1 42.3 66.8  
 Separated/divorced/widowed 20.3 17.4 34.4 18.5   21.5 25.0 40.1 22.3   16.4 16.3 29.7 17.0  
Age at diagnosis 69.7 ± 12.6 68.0 ± 14.5 65.3 ± 13.2 66.3 ± 16.8 0.001 63.6 ± 16.3 61.4 ± 16.8 65.5 ± 16.4 64.1 ± 16.1 0.034 58.9 ± 17.2 53.5 ± 18.2 60.3 ± 18.5 57.0 ± 19.3 <0.001
Anatomic Site      <0.001      0.010      <0.001
 Face/head/neck 60.3 70.4 37.0 46.4   1.8 1.3 0.5 0   18.6 17.5 9.9 10.6  
 Trunk 15.3 11.6 8.7 15.9   2.2 1.0 0 0   32.2 24.4 15.4 20.0  
 Upper Extremity 19.3 11.6 6.5 14.5   20.2 16.3 15.3 19.0   23.7 19.7 11.3 17.5  
 Lower Extremity 4.4 6.0 45.7 23.2   75.6 81.0 83.7 79.8   17.5 26.6 43.8 33.6  
 Other 0.6 0.4 2.2 0   0.2 0.3 0.5 1.2   8.0 11.7 19.7 18.4  
Thickness of tumor (mm) 0.70 ± 1.00 0.73 ± 0.85 1.98 ± 2.59 0.96 ± 1.31 <0.001 2.12 ± 2.08 2.38 ± 2.27 2.53 ± 2.39 2.99 ± 2.47 <0.001 1.10 ± 1.47 1.53 ± 1.95 2.42 ± 2.63 1.75 ± 2.08 <0.001
Satellite nodules      <0.001      0.016      <0.001
 No 96.1 97.2 89.1 89.9   94.5 92.7 93.5 86.9   89.3 85.5 79.1 80.8  
 Yes 0.5 0 8.7 2.9   2.8 3.7 3.7 6.5   0.8 1.1 2.7 1.5  
 Unknown 3.4 2.8 2.2 7.2   2.7 3.7 2.8 6.5   9.9 13.4 18.3 17.7  
Ulceration      <0.001      0.025      <0.001
 No 88.8 85.6 67.4 82.6   70.5 65.3 62.3 60.7   78.0 72.2 60.0 65.5  
 Yes 2.9 2.8 8.7 4.3   24.6 29.0 33.0 33.3   6.6 9.7 15.1 10.0  
 Unknown 8.3 11.6 23.9 13.0   4.8 5.7 4.7 6.0   15.3 18.2 24.9 24.5  
Lymph node extension      <0.001      0.001      <0.001
 None 75.8 75.6 63.0 69.6   68.0 70.3 69.3 60.7   71.6 66.6 49.4 54.1  
 Regional 0.7 1.2 6.5 4.3   14.9 20.0 11.6 23.2   4.8 8.6 14.1 9.3  
 Distant 0.1 0 2.2 1.4   0.9 41.3 1.4 0   0.8 1.2 2.7 2.3  
 Unknown 23.4 23.2 28.3 24.6   16.2 8.3 17.7 16.1   22.8 23.6 33.9 34.3  
Stage      <0.001      0.005      <0.001
 In situ - - - -   - - - -   - - - -  
 Localized 93.5 93.2 73.9 85.5   67.7 60.7 66.5 53.0   77.3 66.3 44.7 57.7  
 Regional 3.2 3.2 17.4 8.7   27.2 31.3 26.5 39.9   8.8 14.6 21.1 15.3  
 Distant 0.3 0.4 4.3 1.4   3.3 4.3 4.7 5.4   6.3 10.3 20.6 16.4  
 Unstaged 2.9 3.2 4.3 4.3   1.8 3.7 2.3 1.8   7.7 8.8 13.7 10.6  
Treatment      0.016      0.028      <0.001
 No treatment 2.1 4.0 4.3 1.4   1.8 2.7 3.3 0.6   6.1 11.2 15.4 12.1  
 Surgery 96.2 94.8 93.5 92.8   96.8 94.3 94.4 94.6   88.7 82.5 73.0 78.0  
 Radiation 0.1 0 0 1.4   0.2 0.3 0 0.6   1.7 2.0 4.8 3.9  
 Radiation & Surgery 0.9 0.4 0 2.9   1.3 2.3 2.3 3.6   2.5 3.6 4.1 4.4  
 Unknown 0.6 0.8 2.2 1.4   0 0.3 0 0.6   1.1 0.7 2.8 1.5  
Survival time (month) 181.9 ± 2.0 188.7 ± 14.2 153.0 ± 21.9 237.3 ± 25.1 0.138 158.4 ± 4.0 154.4 ± 10.4 133.4 ± 9.9 130.1 ± 12.1 0.023 243.0 ± 0.9 237.9 ± 5.8 144.6 ± 8.9 215.3 ± 10.1 <0.001
  1. Cancers diagnosed 1973-2011 in the SEER 18 database. For a continuous variable, mean ± standard deviation; For a categorical variable, percentage