Table 1 Patients’ characteristics and clinicopathologic features

NHW (n = 87852)

HW (n = 1890)

Black (n = 222)

Asian/PI (n = 180)

P

NHW (n = 84790)

HW (n = 1993)

Black (n = 218)

Asian/PI (n = 364)

P

NHW (n = 19260)

HW (n = 689)

Black (n = 106)

Asian/PI (n = 160)

P

Gender

<0.001

<0.001

<0.001

 Male

54.7

36.0

45.0

44.6

53.3

35.6

42.2

49.2

61.6

51.8

44.3

56.3

 Female

45.3

64.0

55.0

55.4

46.7

64.4

57.8

50.8

38.4

48.2

55.7

43.8

Marital Status

<0.001

<0.001

<0.001

 Single

12.6

15.4

22.1

18.8

15.4

18.8

26.3

23.9

14.9

21.3

37.0

17.6

 Married

73.9

70.8

54.7

67.7

71.2

67.7

48.1

62.7

63.5

58.5

34.8

62.0

 Separated/divorced/widowed

13.5

13.8

23.3

13.5

13.4

13.5

25.6

13.4

21.6

20.2

28.3

20.4

Age at diagnosis

60.5 ± 15.9

55.6 ± 16.9

59.2 ± 16.2

55.0 ± 17.9

<0.001

54.7 ± 16.7

49.2 ± 16.5

56.0 ± 17.7

52.7 ± 17.3

<0.001

62.1 ± 17.7

55.9 ± 19.1

62.7 ± 18.1

60.3 ± 20.1

<0.001

Anatomic Site

<0.001

<0.001

<0.001

 Face/head/neck

25.7

28.6

18.0

22.3

13.7

14.4

9.6

11.0

22.9

22.5

15.1

16.9

 Trunk

30.9

24.1

12.6

26.0

39.0

33.9

29.8

36.0

32.1

28.3

18.9

26.3

 Upper Extremity

25.9

23.9

24.8

22.8

25.7

22.9

17.0

18.7

27.1

20.8

12.3

13.8

 Lower Extremity

17.0

23.0

44.1

29.0

21.0

28.4

42.2

33.5

17.4

28.0

51.9

43.1

 Other

0.6

0.5

0.5

0

0.5

0.4

1.4

0.8

0.6

0.4

1.9

0

Thickness of tumor (mm)

0.80 ± 1.83

0.78 ± 1.85

1.02 ± 1.31

0.68 ± 0.88

0.980

0.92 ± 1.09

1.01 ± 1.20

1.51 ± 2.11

1.36 ± 1.96

<0.001

3.27 ± 2.51

3.93 ± 3.02

4.22 ± 3.18

4.23 ± 3.04

<0.001

Satellite nodules

0.012

0.280

 No

-

-

-

-

97.0

97.2

95.9

95.3

93.5

93.9

88.7

95.6

 Yes

-

-

-

-

0.6

1.1

0.9

0.8

3.6

3.5

4.7

3.1

 Unknown

-

-

-

-

2.4

1.7

3.2

3.8

3.0

2.6

6.6

1.3

Ulceration

0.242

0.001

0.001

 No

92.2

91.7

94.1

91.1

86.7

87.6

83.5

87.4

59.8

56.0

50.9

56.3

 Yes

0.5

0.4

0.9

0

4.9

6.0

8.3

6.6

31.4

38.3

37.7

35.6

 Unknown

7.3

7.9

5.0

8.9

8.4

6.4

8.3

6.0

8.8

5.7

11.3

8.1

Lymph node extension

0.866

<0.001

<0.001

 None

99.9

99.8

99.5

100.0

72.7

78.8

67.0

76.9

63.3

60.4

52.8

58.1

 Regional

0

0

0

0

3.2

4.7

5.0

6.6

16.6

25.3

18.9

25.0

 Distant

0

0

0

0

0.1

0.2

0

0

0.9

2.0

5.7

1.9

 Unknown

0.1

0.2

0.5

0

24.0

16.3

28.0

16.5

19.2

12.3

22.6

15.0

Stage

0.996

<0.001

<0.001

 In situ

100.0

100.0

100.0

100.0

-

-

-

-

-

-

-

-

 Localized

-

-

-

-

92.7

90.8

86.7

87.9

62.1

51.1

43.4

52.5

 Regional

-

-

-

-

5.4

7.4

9.6

9.6

32.0

40.1

38.7

41.3

 Distant

-

-

-

-

0.4

0.8

0.9

0.8

4.1

7.1

14.2

5.6

 Unstaged

0.0

-

-

-

1.5

1.1

2.8

1.6

1.9

1.7

3.8

0.6

Treatment

0.152

0.005

0.033

 No treatment

4.1

5.8

5.0

4.2

1.6

2.0

1.4

2.2

1.5

1.6

1.9

1.3

 Surgery

95.1

93.7

94.6

95.3

97.1

97.1

95.4

95.6

94.7

94.8

90.6

93.8

 Radiation

0.1

0.1

0

0.2

0.1

0

0.5

0

0.2

0

0

1.3

 Radiation & Surgery

0.4

0.3

0

0

0.9

0.8

1.4

1.9

3.3

3.2

5.7

3.1

 Unknown

0.2

0.2

0.5

0.2

0.4

0.1

1.4

0.3

0.4

0.4

1.9

0.6

Type of surgery

<0.001

<0.001

<0.001

 No surgery

4.2

5.9

5.1

4.5

1.7

2.1

1.6

2.3

1.8

1.7

2.0

2.1

 Biopsy

65.8

63.9

51.6

55.8

43.0

43.6

37.0

42.9

32.5

35.1

34.3

32.9

 Wide excision

29.8

29.9

40.0

39.3

55.0

53.5

59.3

54.2

64.3

57.3

57.6

60.3

 Amputation

0.1

0.2

2.8

0.5

0.1

0.4

2.1

0.3

0.5

3.5

3.0

4.1

 Surgery NOS

0.1

0.1

0.5

0

0.3

0.5

0

0.3

0.9

2.4

3.0

0.7

Survival time (month)

300.7 ± 3.0

355.9 ± 13.1

287.8 ± 15.3

325.6 ± 19.6

<0.001

298.7 ± 1.2

305.8 ± 6.3

277.1 ± 17.5

300.2 ± 13.6

0.001

168.5 ± 1.8

160.3 ± 9.6

106.9 ± 14.3

145.8 ± 16.6

0.033

NHW (n = 17226)

HW (n = 250)

Black (n = 46)

Asian/PI (n = 69)

P

NHW (n = 1822)

HW (n = 300)

Black (n = 215)

Asian/PI (n = 168)

P

NHW (n = 127924)

HW (n = 3807)

Black (n = 788)

Asian/PI (n = 861)

P

Gender

<0.001

0.138

<0.001

 Male

67.2

54.4

54.3

56.5

46.5

46.3

40.9

53.0

57.5

42.6

48.4

48.5

 Female

32.8

45.6

45.7

43.5

53.5

53.7

59.1

47.0

42.5

57.4

51.6

51.5

Marital Status

0.283

<0.001

<0.001

 Single

8.3

11.6

6.3

7.4

12.9

15.2

17.3

10.2

14.8

20.5

28.0

16.2

 Married

71.4

71.1

59.4

74.1

65.7

59.8

42.6

67.5

68.8

63.1

42.3

66.8

 Separated/divorced/widowed

20.3

17.4

34.4

18.5

21.5

25.0

40.1

22.3

16.4

16.3

29.7

17.0

Age at diagnosis

69.7 ± 12.6

68.0 ± 14.5

65.3 ± 13.2

66.3 ± 16.8

0.001

63.6 ± 16.3

61.4 ± 16.8

65.5 ± 16.4

64.1 ± 16.1

0.034

58.9 ± 17.2

53.5 ± 18.2

60.3 ± 18.5

57.0 ± 19.3

<0.001

Anatomic Site

<0.001

0.010

<0.001

 Face/head/neck

60.3

70.4

37.0

46.4

1.8

1.3

0.5

0

18.6

17.5

9.9

10.6

 Trunk

15.3

11.6

8.7

15.9

2.2

1.0

0

0

32.2

24.4

15.4

20.0

 Upper Extremity

19.3

11.6

6.5

14.5

20.2

16.3

15.3

19.0

23.7

19.7

11.3

17.5

 Lower Extremity

4.4

6.0

45.7

23.2

75.6

81.0

83.7

79.8

17.5

26.6

43.8

33.6

 Other

0.6

0.4

2.2

0

0.2

0.3

0.5

1.2

8.0

11.7

19.7

18.4

Thickness of tumor (mm)

0.70 ± 1.00

0.73 ± 0.85

1.98 ± 2.59

0.96 ± 1.31

<0.001

2.12 ± 2.08

2.38 ± 2.27

2.53 ± 2.39

2.99 ± 2.47

<0.001

1.10 ± 1.47

1.53 ± 1.95

2.42 ± 2.63

1.75 ± 2.08

<0.001

Satellite nodules

<0.001

0.016

<0.001

 No

96.1

97.2

89.1

89.9

94.5

92.7

93.5

86.9

89.3

85.5

79.1

80.8

 Yes

0.5

0

8.7

2.9

2.8

3.7

3.7

6.5

0.8

1.1

2.7

1.5

 Unknown

3.4

2.8

2.2

7.2

2.7

3.7

2.8

6.5

9.9

13.4

18.3

17.7

Ulceration

<0.001

0.025

<0.001

 No

88.8

85.6

67.4

82.6

70.5

65.3

62.3

60.7

78.0

72.2

60.0

65.5

 Yes

2.9

2.8

8.7

4.3

24.6

29.0

33.0

33.3

6.6

9.7

15.1

10.0

 Unknown

8.3

11.6

23.9

13.0

4.8

5.7

4.7

6.0

15.3

18.2

24.9

24.5

Lymph node extension

<0.001

0.001

<0.001

 None

75.8

75.6

63.0

69.6

68.0

70.3

69.3

60.7

71.6

66.6

49.4

54.1

 Regional

0.7

1.2

6.5

4.3

14.9

20.0

11.6

23.2

4.8

8.6

14.1

9.3

 Distant

0.1

0

2.2

1.4

0.9

41.3

1.4

0

0.8

1.2

2.7

2.3

 Unknown

23.4

23.2

28.3

24.6

16.2

8.3

17.7

16.1

22.8

23.6

33.9

34.3

Stage

<0.001

0.005

<0.001

 In situ

-

-

-

-

-

-

-

-

-

-

-

-

 Localized

93.5

93.2

73.9

85.5

67.7

60.7

66.5

53.0

77.3

66.3

44.7

57.7

 Regional

3.2

3.2

17.4

8.7

27.2

31.3

26.5

39.9

8.8

14.6

21.1

15.3

 Distant

0.3

0.4

4.3

1.4

3.3

4.3

4.7

5.4

6.3

10.3

20.6

16.4

 Unstaged

2.9

3.2

4.3

4.3

1.8

3.7

2.3

1.8

7.7

8.8

13.7

10.6

Treatment

0.016

0.028

<0.001

 No treatment

2.1

4.0

4.3

1.4

1.8

2.7

3.3

0.6

6.1

11.2

15.4

12.1

 Surgery

96.2

94.8

93.5

92.8

96.8

94.3

94.4

94.6

88.7

82.5

73.0

78.0

 Radiation

0.1

0

0

1.4

0.2

0.3

0

0.6

1.7

2.0

4.8

3.9

 Radiation & Surgery

0.9

0.4

0

2.9

1.3

2.3

2.3

3.6

2.5

3.6

4.1

4.4

 Unknown

0.6

0.8

2.2

1.4

0

0.3

0

0.6

1.1

0.7

2.8

1.5

Survival time (month)

181.9 ± 2.0

188.7 ± 14.2

153.0 ± 21.9

237.3 ± 25.1

0.138

158.4 ± 4.0

154.4 ± 10.4

133.4 ± 9.9

130.1 ± 12.1

0.023

243.0 ± 0.9

237.9 ± 5.8

144.6 ± 8.9

215.3 ± 10.1

<0.001