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Fig. 4 | BMC Cancer

Fig. 4

From: Deferasirox, a novel oral iron chelator, shows antiproliferative activity against pancreatic cancer in vitro and in vivo

Fig. 4

DFX increased caspase 3/7 activity in pancreatic cancer cell lines. BxPC-3, HPAF-II, and Panc 10.05 cells were incubated with the vehicle control (PBS) or DFX at concentrations of 10, 50, or 100 μM for 48 h. Immediately after the incubation, caspase 3/7 activity was measured using a luminescence assay and corrected for cell viability determined using the MTS assay. The corrected caspase 3/7 activities of BxPC-3, HPAF-II, and Panc 10.05 cells incubated with DFX increased in a dose-dependent manner. The data are presented as the mean ± SD (n = 3). *p <0.05, **p <0.01 vs. control

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BMC Cancer

ISSN: 1471-2407

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