Serum biomarker and study group | Level changesa | ||||||
---|---|---|---|---|---|---|---|
Δδ day 14 of cycle 1 - baseline | P value | Δδ day 1 of cycle 2 - baseline | P value | Δδ day 1 of cycle 3 - baseline | P value | ||
VEGF-A | Sunitinib | -0.6816 (1.43) | 0.017 | -0.1393 (1.83) | 0.831 | 0.1111 (1.26) | 0.975 |
Placebo | -0.3134 (1.24) | 0.472 | -0.7184 (1.32) | 0.033 | -1.1177 (1.92) | 0.062 | |
sVEGFR2 | Sunitinib | -0.0648 (0.17) | 0.012 | -0.0854 (0.12) | 0.006 | -0.0727 (0.14) | 0.078 |
Placebo | -0.0086 (0.12) | 0. 222 | -0.0216 (0.10) | 0.472 | 0.0306 (0.20) | 0.910 | |
VEGF-D | Sunitinib | 0.2476 (0.26) | <0.001 | 0.1038 (0.27) | 0.131 | 0.0914 (0.20) | 0.133 |
Placebo | -0.1093 (0.66) | 0.616 | -0.0094 (0.19) | 0.811 | -0.1061 (0.25) | 0.281 | |
SDF-1α | Sunitinib | 0.0914 (0.47) | 0.756 | 0.2912 (0.92) | 0.730 | - | - |
Placebo | -0.0827 (0.93) | 0.820 | 0.3572 (0.85) | 0.041 | - | - |