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Table 5 Summary of results following treatment of A2780cisR cell line with CS administered in two aliquots with 2 h time gap

From: Changes in the in vitro activity of platinum drugs when administered in two aliquots

  Cytotoxic effect Cellular accumulation DNAbinding Proteomicsa
  Fresh Aged Fresh Aged Fresh Aged Fresh Aged
CS + CS
2 h Antagonistic Synergistic Unchanged Increased Increased Greater increase COF2
MARE1
NPM
ANXA1
RSSA
ACTB
CALU
HNRPF
ATPA
HNRPK
CH60
TCPQ
GLU2B
HSP74
HNRPC
CALR
VIME
(D,R),
(D,R),
(D,R),
(D,R),
(U,R),
(U,R),
(U,OR),
(D,R),
(U,OR),
(U,OR),
(U,OR),
(D,OR),
(U,OR),
(D,OR),
(U,R),
(U,R),
(U,OR).
COX5A
COF2
1433γ
MARE1
NPM
ANXA1
HNRPF
ENOA
ATPA
PDIA3
TCPQ
GRP75
HNRPC
CALR
(D,OR),
(D,OR),
(D,OR),
(D,OR),
(D,OR),
(D,OR),
(D,OR),
(D,R),
(U,OR),
(D,R),
(D,R),
(D,R),
(U,R),
(U,OR).
  1. aThe proteins listed have been fully/over restored in A2780cisR due to the selected combinations as compared to the parent A2780 cell line. Keys: U = up-regulated, D = down-regulated, OR = over-restored, R = fully-restored