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Table 5 Summary of results following treatment of A2780cisR cell line with CS administered in two aliquots with 2 h time gap

From: Changes in the in vitro activity of platinum drugs when administered in two aliquots

 

Cytotoxic effect

Cellular accumulation

DNAbinding

Proteomicsa

 

Fresh

Aged

Fresh

Aged

Fresh

Aged

Fresh

Aged

CS + CS

2 h

Antagonistic

Synergistic

Unchanged

Increased

Increased

Greater increase

COF2

MARE1

NPM

ANXA1

RSSA

ACTB

CALU

HNRPF

ATPA

HNRPK

CH60

TCPQ

GLU2B

HSP74

HNRPC

CALR

VIME

(D,R),

(D,R),

(D,R),

(D,R),

(U,R),

(U,R),

(U,OR),

(D,R),

(U,OR),

(U,OR),

(U,OR),

(D,OR),

(U,OR),

(D,OR),

(U,R),

(U,R),

(U,OR).

COX5A

COF2

1433γ

MARE1

NPM

ANXA1

HNRPF

ENOA

ATPA

PDIA3

TCPQ

GRP75

HNRPC

CALR

(D,OR),

(D,OR),

(D,OR),

(D,OR),

(D,OR),

(D,OR),

(D,OR),

(D,R),

(U,OR),

(D,R),

(D,R),

(D,R),

(U,R),

(U,OR).

  1. aThe proteins listed have been fully/over restored in A2780cisR due to the selected combinations as compared to the parent A2780 cell line. Keys: U = up-regulated, D = down-regulated, OR = over-restored, R = fully-restored