Signaling component | Normal | CRC II | CRC IV | Comment |
---|---|---|---|---|
EGFR | + | + | + | Similar levels in benign, CRC II and IV. |
pAKT/AKT | + | + | + | Total levels of pAKT and AKT upregulated in CRC but pAKT/AKT ratios were similar in the different samples. |
p70S6K | + | + | + | Similar levels in benign, CRC II and IV. |
PLCγ1 | - | +++ | + + | Low or no PLCγ1 expression in benign samples and higher levels in CRC. pPLCγ1 was not detected in any samples. |
SRC pY527/SRC | +++ | + | + | Low or no SRC pY418 in all samples. Lower SRC pY527/SRC ratios in CRC II and IV compared to benign. |
pERK1/ERK1 | +++ | + | + | Reduced pERK1/ERK1 ratio in CRC II and IV compared to benign. |
pERK2/ERK2 | ++ | ++ | ++ | Similar ratios benign, CRC II and IV. |
MEK1/2 | + | + | + | Similar levels in benign, CRC II and IV. |