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Table 1 Summary of changes in signaling components between normal and CRC tissues

From: High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer

Signaling component Normal CRC II CRC IV Comment
EGFR + + + Similar levels in benign, CRC II and IV.
pAKT/AKT + + + Total levels of pAKT and AKT upregulated in CRC but pAKT/AKT ratios were similar in the different samples.
p70S6K + + + Similar levels in benign, CRC II and IV.
PLCγ1 - +++ + + Low or no PLCγ1 expression in benign samples and higher levels in CRC. pPLCγ1 was not detected in any samples.
SRC pY527/SRC +++ + + Low or no SRC pY418 in all samples. Lower SRC pY527/SRC ratios in CRC II and IV compared to benign.
pERK1/ERK1 +++ + + Reduced pERK1/ERK1 ratio in CRC II and IV compared to benign.
pERK2/ERK2 ++ ++ ++ Similar ratios benign, CRC II and IV.
MEK1/2 + + + Similar levels in benign, CRC II and IV.
  1. +, ++ and +++ indicate different relative levels or ratios for a particular signaling component when comparing normal, CRCII and CRCIV samples, and should not be applied to compare levels/ratios between the different signaling components