| | |
Homozygote (AA vs. aa)
|
Heterozygote (Aa vs. aa)
|
Dominant model (AA + Aa vs. aa)
|
Recessive model (AA vs. Aa + aa)
|
|---|
|
Analysis
|
N
|
OR (95 % CI)
|
P
|
I2 (%)
|
OR (95 % CI)
|
P
|
I2 (%)
|
OR (95 % CI)
|
P
|
I2 (%)
|
OR (95 % CI)
|
P
|
I2 (%)
|
|---|
|
Overall
|
9
|
0.97 (0.76–1.25)
|
0.85
|
51.1
|
1.00 (0.88–1.13)
|
0.99
|
28.8
|
0.98 (0.87–1.10)
|
0.79
|
0
|
0.97 (0.85–1.01)
|
0.64
|
0
|
|
Ethnicity
|
|
Caucasian
|
4
|
0.81 (0.66–1.01)
|
0.06
|
11.0
|
1.01 (0.85–1.19)
|
0.91
|
20.8
|
0.94 (0.81–1.10)
|
0.46
|
20.8
|
0.92 (0.78–1.06)
|
0.25
|
0
|
|
African American
|
2
|
1.54 (0.74–3.19)
|
0.24
|
57.9
|
1.16 (0.84–1.60)
|
0.35
|
0
|
1.27 (0.94–1.72)
|
0.12
|
0
|
0.92 (0.65–1.29)
|
0.63
|
0
|
|
Asian
|
6
|
1.05 (0.69–1.58)
|
0.82
|
36.2
|
0.90 (0.71–1.14)
|
0.40
|
49.0
|
0.93 (0.76–1.16)
|
0.56
|
0
|
1.24 (0.92–1.66)
|
0.14
|
0
|
|
Source of control
|
|
PB
|
8
|
1.03 (0.77–1.38)
|
0.82
|
60.1
|
1.05 (0.91–1.20)
|
0.52
|
42.9
|
1.02 (0.90–1.16)
|
0.72
|
0
|
0.97 (0.85–1.11)
|
0.64
|
17.8
|
|
HB
|
4
|
0.82 (0.50–1.34)
|
0.43
|
29.3
|
0.83 (0.63–1.10)
|
0.20
|
0
|
0.84 (0.65–1.09)
|
0.18
|
0
|
0.98 (0.69–1.38)
|
0.92
|
0
|
|
HWE in controls
|
|
Yes
|
10
|
0.96 (0.76–1.21)
|
0.733
|
36.6
|
1.01 (0.89–1.15)
|
0.90
|
0
|
0.99 (0.87–1.12)
|
0.86
|
0
|
0.93 (0.82–1.06)
|
0.29
|
0
|
|
No
|
2
|
0.86 (0.19–3.86)
|
0.84
|
86.7
|
0.91 (0.59–1.40)
|
0.66
|
85.6
|
0.98 (0.88–1.10)
|
0.74
|
0
|
1.56 (0.99–2.46)
|
0.05
|
0
|
-
P P values for Z test, OR odds ratio, CI confidence intervals, HB hospital–based studies, PB population-based studies, HWE Hardy–Weinberg equilibrium, NR not reported
