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Table 1 Previously reported antemortem diagnoses of PTTM

From: Antemortem diagnosis of pulmonary tumor thrombotic microangiopathy in a patient with recurrent breast cancer: a case report

Year Author Primary site Diagnostic method of PTTM CT findings PH Treatment Survival time
2007 Miyano et al. [5] Stomach VATS Multiple tiny nodules - S-1 + dexamethasone
+ warfarin, aspirin
9 months
2008 Noguchi et al. [12] Stomach TBLB Tiny nodules + No treatment 10 days
2008 Uruga et al. [8] Lung CT guided biopsy Consolidation, ground glass attenuation - Carboplatin, paclitaxel 7 months
2011 Ishiguro et al. [2] Unknown TBLB Mild interlobular septal thickening, ground glass opacities + CHOP(cyclophosphamide, doxorubicin, vincristine, prednisolone) 4 months
2011 Ueda et al. [7] Esophagus TBLB Multiple bilateral diffuse interstitial infiltrative shadows + Fluorouracil, nedaplatin 9 days
2012 Kayatani et al. [3] Unknown VATS Centrilobular ultrafine granular shadows - S-1, cisplatin 15 months
2013 Ogawa et al. [6] Gastroduodenum TBLB A nodular shadow and septal thicken with a slight amount of pleural effusion + Bosentan, epoprostenol
+ imatinib
+ S-1, 5-fluorouracil
9 months
2013 Kitamura et al. [4] Breast TBLB Ground glass opacities around the bronchovascular bundles - Irinotecan + warfarin 3 months
2014 Higo et al. [13] Breast Pulmonary wedge aspiration Mosaic pattern + Bosentan, tadalafil
+ imatinib, bevacizumab + S-1
12 months
2015 Takahashi et al. (present case) Breast VATS Peripheral consolidation in both lower lobes - Trastuzumab 32 months
  1. PTTM Pulmonary tumor thrombotic microangiopathy, PH pulmonary hypertension, TBLB transbronchial lung biopsy, VATS Video-assisted thoracoscopic surgery, S-1 tegafur, gimeracil oteracil potassium