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Table 5 Cox regression model to determine the effect of each symptom-to-diagnosis interval quartile on survival, adjusting for a) age, gender and b) age, gender and stage at diagnosis

From: Effect of diagnostic delay on survival in patients with colorectal cancer: a retrospective cohort study

  Total Colon Rectum
P HR 95 % CI P HR 95 % CI P HR 95 % CI
a) Model 1
Age <0.001 1.02 1.01–1.03 <0.001 1.01 1.01–1.03 0.007 1.02 1.01–1.04
Gender (female) 0.029 0.81 0.67–0.98 0.009 0.73 0.58–0.92 0.872 1.03 0.73–1.45
SDI quartile 0.079    0.282    0.003   
 1st quartile   1    1    1  
 2nd quartile 0.979 1.00 0.75–1.34 0.798 1.04 0.76–1.43 0.022 0.59 0.38–0.93
 3rd quartile 0.089 0.77 0.57–1.04 0.600 0.92 0.67–1.26 0.004 0.50 0.31–0.80
 4rd quartile 0.104 0.78 0.59–1.05 0.115 0.76 0.54–1.07 0.001 0.46 0.29–0.74
b) Model 2
Age <0.001 1.02 1.01–1.03 0.001 1.02 1.01–1.03 0.003 1.03 1.01–1.05
Gender (female) 0.143 0.86 0.70–1.05 0.109 0.85 0.63–1.05 0.835 0.96 0.66–1.40
SDI quartile 0.115    0.160    0.084   
 1st quartile   1    1    1  
 2nd quartile 0.855 0.97 0.71–1.32 0.854 0.97 0.69–1.36 0.534 0.85 0.52–1.40
 3rd quartile 0.088 0.76 0.55–1.04 0.176 0.79 0.56–1.11 0.003 0.56 0.34–0.94
 4rd quartile 0.100 0.77 0.56–1.05 0.052 0.70 0.49–1.01 0.006 0.58 0.33–1.02
TNM stage at diagnosis <0.001    <0.001    <0.001   
 I   1    1    1  
 II 0.002 2.07 1.29–3.33 0.083 1.72 0.93–3.18 0.003 3.23 1.51–6.92
 III <0.001 3.17 1.99–5.05 0.002 2.57 1.40–4.72 <0.001 4.94 2.38–10.24
 IV <0.001 12.40 7.56–19.81 <0.001 10.10 5.47–18.61 <0.001 19.07 9.05–40.15
  1. HR Hazard Ratio, CI Confidence Interval, SDI Symptoms-to-Diagnosis Interval