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Fig. 8 | BMC Cancer

Fig. 8

From: p53, cathepsin D, Bcl-2 are joint prognostic indicators of breast cancer metastatic spreading

Fig. 8

TP53 coding regions sequencing. a Block scheme of the p53 functional domains, protein sequence residues numbers are shown; Pro rich: proline-rich; tetra: oligomerization domain; reg: negative regulator of p53 function. b Prevalence of TP53 mutations in the different regions of the gene (from IARC TP53 Database, Release 17); (top) frequency of somatic mutations in BC; (bottom) frequency of germline, hereditary mutations in Li-Fraumeni syndrome. c Representative example of a DNA sequence chromatogram, containing a mutated sequence (see also Additional file 5: Table S5); the mutation site is boxed; the corresponding amino acid sequence is indicated

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