Fig. 2

Expression of cathepsin D in BC Representative examples are shown. Positive/high (left column) versus negative/low (right column) cases for expression of cathepsin D and MMP11 are indicated. Nuclei were counterstained with Mayer’s hematoxylin (in blue). a, b Tumor cases with high cathepsin D expression both in cells and in the stroma between the tumor cells. c, d Tumor cases with low/nil cathepsin D expression in cells, but with detectable expression in the tumor stroma. e Case with high cathepsin D expression in tumor cells, but no expression in the stroma. f Case with no cathepsin D expression in tumor cells, but high expression in the stroma. g Case with low/nil cathepsin D expression in both tumor cells and stroma. h Negative control for staining. Original magnification: ×400