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Fig. 1 | BMC Cancer

Fig. 1

From: Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models

Fig. 1

a IC50 doses of dactolisib for P3 (left) and U87 (right) glioma cells, generated from MTS assay. b Relative cell number of P3 (left) and U87 (right) glioma cells exposed to dactolisib at doses indicated for 72 h. c Quantification of BrdU positive P3 (left) and U87 (right) glioma cells treated with dactolisib at doses indicated for 72 h and subsequently pulsed with BrdU. d Quantification of Annexin V- and PI-positive P3 (left) and U87 (right) glioma cells treated with dactolisib at doses indicated for 72 h and subsequently incubated with PI and Annexin V Alexa Fluor 488 conjugate. Error bars represent s.d. of three independent experiments. *P <0.05, **P < 0.01, ***P < 0,001, ****P < 0,0001

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