Table 3 Pooled HRs 95 % Cl for toxicity between CRT & BRT
Comparison | Adverse event/ Toxicity | Study N. | Model | HR 95 % [Cl] | P value | Heterogeneity (p ,I2) | Conclusion |
|---|---|---|---|---|---|---|---|
CRT vs. BRT | Mucositis | 7 | Fixed | 0.05 [-0.09, 0.19] | p=0.493 | P = 0.45; I² = 36.9 % | Negative |
CRT vs. BRT | Dysphagia | 5 | Fixed | -0.07 [-0.35, 0.21], | p=0.63 | P = 0.89; I² = 0 % | Negative |
CRT vs. BRT | Xerostomia | 2 | Fixed | 0.51 [0.09, 2.95], | p=0.46 | P = 0.17; I² = 46 % | Negative |
CRT vs. BRT | Laryngeal edema | 2 | Fixed | 0.91 [0.71, 1.18] | p=0.49 | P = 0.89; I² = 0 % | Negative |
CRT vs. BRT | Acute kidney injury | 5 | Fixed | -1.30 [-2.11, -0.49] | p=0.002 | P = 0.32; I² = 0 % | Positive |
CRT vs. BRT | Nausea or vomiting | 4 | Random | -1.30 [-2.66, 0.06], | p=0.061 | P = 0.03; I² = 57.2 % | Negative |
CRT vs. BRT | Radiation dermatitis | 4 | Random | 0.31 [-0.45, 1.08] | p=0.419 | P = 0.001; I² = 87.6 % | Negative |
CRT vs. BRT | Acneiform rash | 5 | Random | 3.49 [1.23, 5.74] | P=0.002 | P = 0.87; I² = 81 % | Positive |
CRT vs. BRT | Neutropenia | 3 | Fixed | -0.88 [-1.42, -0.33] | p=0.002 | P < 0.00001; I² = 0.0 % | Positive |
CRT vs. BRT | Ototoxicity | 3 | Fixed | 0.16 [0.04, 0.69] | p=0.10 | P = 0.60; I² = 0 % | Negative |
CRT vs. BRT | Infectious | 2 | Fixed | 3.31 [0.55, 19.87] | p=0.19 | P = 0.59; I² = 0 % | Negative |
CRT vs. BRT | Neuropathy | 2 | Fixed | 0.80 [0.46, 1.41] | p=0.44 | P = 0.37; I² = 0 % | Negative |
CRT vs. BRT | Pain | 2 | Fixed | 0.92 [0.80, 1.06] | p=0.24 | P = 0.74; I² = 0 % | Negative |
CRT vs. BRT | Leukopenia | 4 | Fixed | -0.76 [-1.16, -0.36] | P=0.001 | P = 0.19; I² = 44.2 % | Positive |
CRT vs. BRT | Late toxicity | 4 | Fixed | 1.11 [0.83, 1.47], | p=0.48 | P = 0.53; I² = 0 % | Negative |
CRT vs. BRT | Total toxicity | 21 | Random | -0.34 [-0.72, 0.04] | P=0.079 | P < 0.00001; I² = 91.7 % | Negative |