Table 3 Correlation between Her2/neu protein expression patterns and clinico-pathological features of transitional cell carcinoma of urinary bladder
Features | Number of cases (%) | Her2/Neu protein expression patternsa (%) | p value | ||
|---|---|---|---|---|---|
(0,1+) | (2+) | (3+) | |||
Gender | 0.19 | ||||
 Male | 133 (83 %) | 49 (37 %) | 51 (38 %) | 33 (25 %) |  |
 Female | 27 (17 %) | 15 (55 %) | 7 (26 %) | 5 (19 %) |  |
Age group (years) | 0.92 | ||||
  ≤60 | 70 (44 %) | 27 (39 %) | 26 (37 %) | 17 (24 %) |  |
  >60 | 89 (56 %) | 37 (42 %) | 31 (35 %) | 21 (24 %) |  |
Lymph node involvement | 0.04 | ||||
 Yes | 18 (17 %) | 9 (50 %) | 2 (11 %) | 7 (39 %) |  |
 No | 86 (83 %) | 33 (39 %) | 35 (40 %) | 18 (21 %) |  |
Distant metastasis | 0.07 | ||||
 Yes | 17 (17 %) | 9 (53 %) | 2 (12 %) | 6 (35 %) |  |
 No | 83 (83 %) | 31 (37 %) | 34 (41 %) | 18 (22 %) |  |
Tumor Stage | 0.002 | ||||
 I/II | 100 (76 %) | 37 (37 %) | 43 (43 %) | 20 (20 %) |  |
 III/IV | 32 (24 %) | 18 (56 %) | 3 (10 %) | 11 (34 %) |  |
Tumor grade | 0.62 | ||||
 Low grade | 68 (44 %) | 27 (40 %) | 27 (40 %) | 14 (20 %) |  |
 High grade | 85 (56 %) | 35 (41 %) | 28 (33 %) | 22 (26 %) |  |
Vascular invasion | 0.01 | ||||
 Yes | 18 (17 %) | 10 (55 %) | 1 (6 %) | 7 (39 %) |  |
 No | 86 (83 %) | 31 (36 %) | 36 (42 %) | 19 (22 %) |  |
Recurrence | 0.61 | ||||
 Yes | 39 (26 %) | 14 (36 %) | 15 (38 %) | 10 (26 %) |  |
 No | 113 (74 %) | 47 (42 %) | 40 (35 %) | 26 (23 %) |  |
Status and end point | 0.59 | ||||
 Alive | 107 (68 %) | 41 (38 %) | 41 (38 %) | 25 (24 %) |  |
 Died | 50 (32 %) | 22 (44 %) | 15 (30 %) | 13 (26 %) |  |