Criteria | Possible choices | Our model |
---|---|---|
Dose-toxicity model | Empiric, logistic, power | Empiric |
Prior distribution | Gaussian, exponential | Gaussian |
Target toxicity level | 0 to 100 % | <33 % |
Stopping rule | Unlimited. | A maximum of 6 patients at a single dose. |
Prior skeleton | Unlimited | Conservative, aggressive, step-up, dose-linear, sigmoidal, O’Quigley |
Adaption - Extended CRM | Allocate 1 to 3 patients to each cohort prior to the CRM | Allocate 2 patients to each cohort prior to the CRM |