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Table 1 Model calibration for the continual reassessment method

From: Continual reassessment method for dose escalation clinical trials in oncology: a comparison of prior skeleton approaches using AZD3514 data

Criteria

Possible choices

Our model

Dose-toxicity model

Empiric, logistic, power

Empiric

Prior distribution

Gaussian, exponential

Gaussian

Target toxicity level

0 to 100 %

<33 %

Stopping rule

Unlimited.

A maximum of 6 patients at a single dose.

Prior skeleton

Unlimited

Conservative, aggressive, step-up, dose-linear, sigmoidal, O’Quigley

Adaption - Extended CRM

Allocate 1 to 3 patients to each cohort prior to the CRM

Allocate 2 patients to each cohort prior to the CRM