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Fig. 6 | BMC Cancer

Fig. 6

From: Interleukin 12 shows a better curative effect on lung cancer than paclitaxel and cisplatin doublet chemotherapy

Fig. 6

IL-12-induced IFN-γ suppresses tumor angiogenesis. a Immunofluorescence of tumor tissues in WT and IFN-γ−/− tumor-bearing mice. CD31 and VEGFR3 expression in the lung tumor tissues of WT mice was reduced after IL-12 or PTX + CDDP + IL-12 treatment (original magnification, ×100; scale bar, 100 μm). b Percentage of specimens showing CD31 or VEGFR3 expression. CD31 and VEGFR3 expression in the lung tumor tissues of IFN-γ−/− mice was higher than that of WT. CD31 expression in the lung tumor tissues of WT mice was reduced after IL-12 or PTX + CDDP + IL-12 treatment (n = 3; means ± SEM, **P < 0.01). c Immunofluorescence of tumor tissues in WT and IFN-γ−/− tumor-bearing mice. CD105 expression in the lung tumor tissues of WT mice was reduced after IL-12 or PTX + CDDP + IL-12 treatment (original magnification, ×100; scale bar, 100 μm). d Percentage of specimens showing CD105 expression. CD105 expression in the lung tumor tissues of IFN-γ−/− mice was higher than that of WT. CD105 expression in the lung tumor tissues of WT mice was reduced after IL-12 or PTX + CDDP + IL-12 treatment (n = 3; means ± SEM, **P < 0.01)

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