Fig. 5

The anti-tumor effect of IL-12 is dependent on IFN-γ. a Whole-body imaging of WT and IFN-γ^−/− tumor-bearing mice. Tumors detected in the IFN-γ^−/− groups grew more robustly compared with WT group whether IL-12 was administered or not. b The survival (Kaplan-Meier) curves of the treated animals are shown. A prolonged survival time was observed in the WT + IL-12 group as compared to other groups (log-rank test, P < 0.01). No prolonged survival time was observed in the IFN-γ^−/− + IL-12 group. c The imaging results were quantified and analyzed. The bioluminescence (photos/s) indicated that the tumors in IFN-γ^−/− mice grew more robustly compared to the WT group whether IL-12 was administered or not. (n = 6; means ± SEM, **P < 0.01)