Fig. 4

NK cells are essential for the anti-tumor effects of IL-12. a Whole-body imaging of WT, Nfil3^−/−, CD4^−/− and CD8^−/− tumor-bearing mice. Tumors detected in the Nfil3^−/− group grew more robustly compared to the other groups whether IL-12 was administered or not. b The survival (Kaplan-Meier) curves of the treated animals are shown; No prolonged survival time was observed in the Nfil3^−/− + IL-12 group as compared to the other groups. c The survival (Kaplan-Meier) curves of the treated animals are shown; A prolonged survival time was observed in the WT + IL-12 group as compared to other groups (log-rank test, P < 0.01)