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Fig. 3 | BMC Cancer

Fig. 3

From: Interleukin 12 shows a better curative effect on lung cancer than paclitaxel and cisplatin doublet chemotherapy

Fig. 3

IL-12 activates the immune system and rapidly stimulates NK cells to secrete IFN-γ. a Flow cytometry analysis of IFN-γ-producing lymphocytes isolated from the spleens of tumor-bearing mice. The expression of IFN-γ in NK cells increased significantly after IL-12 or PTX + CDDP + IL-12 treatment as compared to PTX + CDDP treatment or control. b IFN-γ transcript levels in tumor tissues of different groups were measured by quantitative PCR. The IFN-γ transcript levels in IL-12 or PTX + CDDP + IL-12 groups were much higher than those in the PTX + CDDP or control groups. (n = 3; means ± SEM, **P < 0.01). c The IFN-γ serum concentration of different treatments in tumor-bearing mice. The serum IFN-γ levels in IL-12 or PTX + CDDP + IL-12 groups were much higher than those in the PTX + CDDP or control groups. (n = 3; means ± SEM, **P < 0.01). d The percentages of NK1.1+IFN-γ+ and CD3+IFN-γ+ cells in the spleens of tumor-bearing mice in different groups. The percentages of NK1.1+IFN-γ+ in IL-12 or PTX + CDDP + IL-12 groups were much higher than those in the PTX + CDDP or control groups. (n = 6; means ± SEM, **P < 0.01). e The spleen mononuclear cell numbers from tumor-bearing mice. More spleen mononuclear cells were found in the IL-12 or PTX + CDDP + IL-12 groups as compared to PTX + CDDP and control groups. Less spleen mononuclear cells were found in the PTX + CDDP group compared to the control group (n = 6; means ± SEM, *P < 0.05)

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