Fig. 2

Comparison of the efficacy of IL-12 and PTX + CDDP doublet chemotherapy on CT26 tumor-bearing mice. a Whole-body imaging of tumor-bearing mice on different dates. Expansion of the tumors of IL-12 and PTX + CDDP + IL-12 groups was less than that of PTX + CDDP or control groups. b Pathological examination also showed that fewer lung tumor nodes were detected in IL-12 and PTX + CDDP + IL-12 treatment groups as compared to PTX + CDDP and control groups. The arrows indicate the areas of the tumor nodes (magnification × 100; scale bar, 200 μm). c The survival (Kaplan-Meier) curves of the treated animals are shown; A prolonged survival time was observed in PTX + CDDP + IL-12 group as compared to PTX + CDDP or control group (log-rank test, P < 0.01). d The imaging results were quantified and analyzed. The bioluminescence (photos/s) indicated that after IL-12 or PTX + CDDP + IL-12 treatment tumor growth was markedly slowed compared with PTX + CDDP and control groups (n = 3; means ± SEM, *P < 0.05)