Fig. 1

Comparison of the efficacy of IL-12 and PTX + CDDP doublet chemotherapy on LLC tumor-bearing mice. a Treatment regimen in orthotopic lung cancer models. Tumor-bearing mice were treated with PTX + CDDP + IL-12, IL-12, PTX + CDDP, saline (as shown). b Imaging of lung tumor tissues. Fewer lung tumor nodes were detected in IL-12 and PTX + CDDP + IL-12 treatment groups as compared to PTX + CDDP and control groups. c Pathological examination also showed that fewer lung tumor nodes were detected in IL-12 and PTX + CDDP + IL-12 treatment groups as compared to PTX + CDDP and control groups. The arrows indicate the areas of the tumor nodes (magnification × 100; scale bar, 200 μm). d The Imaging results were quantified and analyzed. Bioluminescence (photos/s) indicated that, after IL-12 or PTX + CDDP + IL-12 treatment, living tumor cells were markedly decreased compared with PTX + CDDP and control groups (n = 3; means ± SEM, *P < 0.05). e The survival (Kaplan-Meier) curves of the treated animals are shown; Prolonged survival was observed in IL-12 or PTX + CDDP + IL-12 group as compared to PTX + CDDP or control group (log-rank test, P < 0.01)