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Table 5 Ratio of the probability of carrying BRCA1/2 mutations in the investigated patients collective relying on multiple logistic regression model

From: High prevalence and predominance of BRCA1 germline mutations in Pakistani triple-negative breast cancer patients

   Non-carriers BRCA1 mutation carriers
Variables Level n % n % RP 95%CI P
Family phenotype 1 early onset BC (≤ 30 years) 210 53 21 20 Ref.   < 0.0001
Familial BC 166 42 56 53 4.98 2.77 to 8.97  
Familial BC and OC 22 6 28 27 16.22 7.22 to 36.5  
Histology Ductal 359 90 102 97 Ref.   0.36
Other 39 10 3 3 0.53 0.13 to 2.08  
Tumor grade 1 5 1 0 0 -   0.001
2 116 29 6 6 0.17 0.07 to 0.43  
3 253 64 94 90 Ref.   
Unknown 24 6 5 5 0.39 0.12 to 1.20  
TNBC status Non-TNBC 279 70 34 32 Ref.   < 0.0001
TNBC 119 30 71 68 4.23 2.50 to 7.14  
  1. P values marked in bold are statistically significant
  2. BC breast cancer, OC ovarian cancer, Ref. reference, RP ratio of the probability of carrying BRCA1/2 mutations