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Table 5 Ratio of the probability of carrying BRCA1/2 mutations in the investigated patients collective relying on multiple logistic regression model

From: High prevalence and predominance of BRCA1 germline mutations in Pakistani triple-negative breast cancer patients

  

Non-carriers

BRCA1 mutation carriers

Variables

Level

n

%

n

%

RP

95%CI

P

Family phenotype

1 early onset BC (≤ 30 years)

210

53

21

20

Ref.

 

< 0.0001

Familial BC

166

42

56

53

4.98

2.77 to 8.97

 

Familial BC and OC

22

6

28

27

16.22

7.22 to 36.5

 

Histology

Ductal

359

90

102

97

Ref.

 

0.36

Other

39

10

3

3

0.53

0.13 to 2.08

 

Tumor grade

1

5

1

0

0

-

 

0.001

2

116

29

6

6

0.17

0.07 to 0.43

 

3

253

64

94

90

Ref.

  

Unknown

24

6

5

5

0.39

0.12 to 1.20

 

TNBC status

Non-TNBC

279

70

34

32

Ref.

 

< 0.0001

TNBC

119

30

71

68

4.23

2.50 to 7.14

 
  1. P values marked in bold are statistically significant
  2. BC breast cancer, OC ovarian cancer, Ref. reference, RP ratio of the probability of carrying BRCA1/2 mutations
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BMC Cancer

ISSN: 1471-2407

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