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Table 4 Ratio of the probability of carrying BRCA1/2 mutations in the investigated patients collective based on univariate logistic regression models

From: High prevalence and predominance of BRCA1 germline mutations in Pakistani triple-negative breast cancer patients

  

Non-carriers

BRCA1 mutation carriers

BRCA2 mutation carriers

Variables

Level

n

%

n

%

RP

95 % CI

P

n

%

RP

95 % CI

P

Agea

Cont.

398

100

105

100

0.99

0.97 to 1.01

0.34

20

100

1.01

0.97 to 1.05

0.56

Family phenotype

1 early onset BC (≤ 30 years)

210

53

21

20

Ref.

 

< 0.0001

6

30

Ref.

 

0.13

Familial BC

166

42

56

53

3.37

1.96 to 5.80

 

13

65

2.74

1.02 to 7.37

 

Familial BC and OC

22

6

28

27

12.72

6.22 to 26.0

 

1

5

1.59

0.18 to 13.82

 

Menopausal status

Postmenopausal

68

17

10

10

0.51

0.25 to 1.03

0.17

3

15

0.85

0.24 to 3.00

0.97

Premenopausal

329

83

95

90

Ref.

  

17

85

Ref.

  

Unknown

1

0

0

0

-

  

0

0

-

  

Ethnicity

Other

53

13

12

11

0.77

0.39 to 1.50

0.17

5

25

2.45

0.82 to 7.32

0.25

Pathan

60

15

9

9

0.51

0.24 to 1.07

 

4

20

1.72

0.53 to 0.53

 

Punjabi

285

72

84

80

Ref.

  

11

55

Ref.

  

Histology

Ductal

359

90

102

97

Ref.

 

0.03

18

90

Ref.

 

0.98

Other

39

10

3

3

0.27

0.08 to 0.89

 

2

10

1.02

0.23 to 4.57

 

Tumor size

Unknown

80

20

27

26

1.30

0.76 to 2.23

0.73

4

20

0.91

0.28 to 2.97

0.99

pT1

78

20

19

18

0.94

0.52 to 1.70

 

4

20

0.93

0.28 to 3.05

 

pT2

181

45

47

45

Ref.

  

10

50

Ref.

  

pT3

55

14

11

10

0.77

0.37 to 1.59

 

2

10

0.66

0.14 to 3.09

 

pT4

4

1

1

1

0.96

0.11 to 8.82

 

0

0

-

  

Tumor grade

1

5

1

0

0

-

 

< 0.0001

0

0

-

 

0.16

2

116

29

6

6

0.14

0.06 to 0.33

 

9

45

2.45

0.92 to 6.52

 

3

253

64

94

90

Ref.

  

8

40

Ref.

  

Unknown

24

6

5

5

0.56

0.21 to 1.51

 

3

15

3.95

0.98 to 15.9

 

Lymph node status

Negative

146

37

47

45

1.49

0.95 to 2.34

0.13

6

30

0.73

0.27 to 1.97

0.83

Positive

232

58

50

48

Ref.

  

13

65

Ref.

  

Unknown

20

5

8

8

1.86

0.77 to 4.45

 

1

5

0.89

0.11 to 7.18

 

TNBC status

Non-TNBC

279

70

34

32

Ref.

 

< 0.0001

18

90

Ref.

 

0.07

TNBC

119

30

71

68

4.90

3.09 to 7.77

 

2

10

0.26

0.06 to 1.14

 
  1. P values marked in bold are statistically significant
  2. BC breast cancer, OC ovarian cancer, Ref. reference, RP ratio of the probability of carrying BRCA1/2 mutations
  3. aMedian age (5th and 95th percentiles) were 30 years (23 to 54) for non-carriers, 30 years (24 to 48) for BRCA1, and 32 years (24 to 53) for BRCA2 mutation carriers