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Table 4 Ratio of the probability of carrying BRCA1/2 mutations in the investigated patients collective based on univariate logistic regression models

From: High prevalence and predominance of BRCA1 germline mutations in Pakistani triple-negative breast cancer patients

   Non-carriers BRCA1 mutation carriers BRCA2 mutation carriers
Variables Level n % n % RP 95 % CI P n % RP 95 % CI P
Agea Cont. 398 100 105 100 0.99 0.97 to 1.01 0.34 20 100 1.01 0.97 to 1.05 0.56
Family phenotype 1 early onset BC (≤ 30 years) 210 53 21 20 Ref.   < 0.0001 6 30 Ref.   0.13
Familial BC 166 42 56 53 3.37 1.96 to 5.80   13 65 2.74 1.02 to 7.37  
Familial BC and OC 22 6 28 27 12.72 6.22 to 26.0   1 5 1.59 0.18 to 13.82  
Menopausal status Postmenopausal 68 17 10 10 0.51 0.25 to 1.03 0.17 3 15 0.85 0.24 to 3.00 0.97
Premenopausal 329 83 95 90 Ref.    17 85 Ref.   
Unknown 1 0 0 0 -    0 0 -   
Ethnicity Other 53 13 12 11 0.77 0.39 to 1.50 0.17 5 25 2.45 0.82 to 7.32 0.25
Pathan 60 15 9 9 0.51 0.24 to 1.07   4 20 1.72 0.53 to 0.53  
Punjabi 285 72 84 80 Ref.    11 55 Ref.   
Histology Ductal 359 90 102 97 Ref.   0.03 18 90 Ref.   0.98
Other 39 10 3 3 0.27 0.08 to 0.89   2 10 1.02 0.23 to 4.57  
Tumor size Unknown 80 20 27 26 1.30 0.76 to 2.23 0.73 4 20 0.91 0.28 to 2.97 0.99
pT1 78 20 19 18 0.94 0.52 to 1.70   4 20 0.93 0.28 to 3.05  
pT2 181 45 47 45 Ref.    10 50 Ref.   
pT3 55 14 11 10 0.77 0.37 to 1.59   2 10 0.66 0.14 to 3.09  
pT4 4 1 1 1 0.96 0.11 to 8.82   0 0 -   
Tumor grade 1 5 1 0 0 -   < 0.0001 0 0 -   0.16
2 116 29 6 6 0.14 0.06 to 0.33   9 45 2.45 0.92 to 6.52  
3 253 64 94 90 Ref.    8 40 Ref.   
Unknown 24 6 5 5 0.56 0.21 to 1.51   3 15 3.95 0.98 to 15.9  
Lymph node status Negative 146 37 47 45 1.49 0.95 to 2.34 0.13 6 30 0.73 0.27 to 1.97 0.83
Positive 232 58 50 48 Ref.    13 65 Ref.   
Unknown 20 5 8 8 1.86 0.77 to 4.45   1 5 0.89 0.11 to 7.18  
TNBC status Non-TNBC 279 70 34 32 Ref.   < 0.0001 18 90 Ref.   0.07
TNBC 119 30 71 68 4.90 3.09 to 7.77   2 10 0.26 0.06 to 1.14  
  1. P values marked in bold are statistically significant
  2. BC breast cancer, OC ovarian cancer, Ref. reference, RP ratio of the probability of carrying BRCA1/2 mutations
  3. aMedian age (5th and 95th percentiles) were 30 years (23 to 54) for non-carriers, 30 years (24 to 48) for BRCA1, and 32 years (24 to 53) for BRCA2 mutation carriers