|  | Non-carriers | BRCA1 mutation carriers | BRCA2 mutation carriers | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Variables | Level | n | % | n | % | RP | 95 % CI | P | n | % | RP | 95 % CI | P |
Agea | Cont. | 398 | 100 | 105 | 100 | 0.99 | 0.97 to 1.01 | 0.34 | 20 | 100 | 1.01 | 0.97 to 1.05 | 0.56 |
Family phenotype | 1 early onset BC (≤ 30 years) | 210 | 53 | 21 | 20 | Ref. |  | < 0.0001 | 6 | 30 | Ref. |  | 0.13 |
Familial BC | 166 | 42 | 56 | 53 | 3.37 | 1.96 to 5.80 | Â | 13 | 65 | 2.74 | 1.02 to 7.37 | Â | |
Familial BC and OC | 22 | 6 | 28 | 27 | 12.72 | 6.22 to 26.0 | Â | 1 | 5 | 1.59 | 0.18 to 13.82 | Â | |
Menopausal status | Postmenopausal | 68 | 17 | 10 | 10 | 0.51 | 0.25 to 1.03 | 0.17 | 3 | 15 | 0.85 | 0.24 to 3.00 | 0.97 |
Premenopausal | 329 | 83 | 95 | 90 | Ref. | Â | Â | 17 | 85 | Ref. | Â | Â | |
Unknown | 1 | 0 | 0 | 0 | - | Â | Â | 0 | 0 | - | Â | Â | |
Ethnicity | Other | 53 | 13 | 12 | 11 | 0.77 | 0.39 to 1.50 | 0.17 | 5 | 25 | 2.45 | 0.82 to 7.32 | 0.25 |
Pathan | 60 | 15 | 9 | 9 | 0.51 | 0.24 to 1.07 | Â | 4 | 20 | 1.72 | 0.53 to 0.53 | Â | |
Punjabi | 285 | 72 | 84 | 80 | Ref. | Â | Â | 11 | 55 | Ref. | Â | Â | |
Histology | Ductal | 359 | 90 | 102 | 97 | Ref. | Â | 0.03 | 18 | 90 | Ref. | Â | 0.98 |
Other | 39 | 10 | 3 | 3 | 0.27 | 0.08 to 0.89 | Â | 2 | 10 | 1.02 | 0.23 to 4.57 | Â | |
Tumor size | Unknown | 80 | 20 | 27 | 26 | 1.30 | 0.76 to 2.23 | 0.73 | 4 | 20 | 0.91 | 0.28 to 2.97 | 0.99 |
pT1 | 78 | 20 | 19 | 18 | 0.94 | 0.52 to 1.70 | Â | 4 | 20 | 0.93 | 0.28 to 3.05 | Â | |
pT2 | 181 | 45 | 47 | 45 | Ref. | Â | Â | 10 | 50 | Ref. | Â | Â | |
pT3 | 55 | 14 | 11 | 10 | 0.77 | 0.37 to 1.59 | Â | 2 | 10 | 0.66 | 0.14 to 3.09 | Â | |
pT4 | 4 | 1 | 1 | 1 | 0.96 | 0.11 to 8.82 | Â | 0 | 0 | - | Â | Â | |
Tumor grade | 1 | 5 | 1 | 0 | 0 | - |  | < 0.0001 | 0 | 0 | - |  | 0.16 |
2 | 116 | 29 | 6 | 6 | 0.14 | 0.06 to 0.33 | Â | 9 | 45 | 2.45 | 0.92 to 6.52 | Â | |
3 | 253 | 64 | 94 | 90 | Ref. | Â | Â | 8 | 40 | Ref. | Â | Â | |
Unknown | 24 | 6 | 5 | 5 | 0.56 | 0.21 to 1.51 | Â | 3 | 15 | 3.95 | 0.98 to 15.9 | Â | |
Lymph node status | Negative | 146 | 37 | 47 | 45 | 1.49 | 0.95 to 2.34 | 0.13 | 6 | 30 | 0.73 | 0.27 to 1.97 | 0.83 |
Positive | 232 | 58 | 50 | 48 | Ref. | Â | Â | 13 | 65 | Ref. | Â | Â | |
Unknown | 20 | 5 | 8 | 8 | 1.86 | 0.77 to 4.45 | Â | 1 | 5 | 0.89 | 0.11 to 7.18 | Â | |
TNBC status | Non-TNBC | 279 | 70 | 34 | 32 | Ref. |  | < 0.0001 | 18 | 90 | Ref. |  | 0.07 |
TNBC | 119 | 30 | 71 | 68 | 4.90 | 3.09 to 7.77 | Â | 2 | 10 | 0.26 | 0.06 to 1.14 | Â |