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Table 1 Selected clinical and pathological characteristics of the 523 Pakistani cases according to TNBC status

From: High prevalence and predominance of BRCA1 germline mutations in Pakistani triple-negative breast cancer patients

Parameters TNBC (N = 192) Non-TNBC (N = 331) P a
n (%) n (%)
Age at diagnosis of BC (years)
 Mean 31.6 35.6 < 0.0001 b
 Range 18–67 19–73  
Family phenotype
 1 early-onset BC (≤30 years) 90 (46.9) 147 (44.4) NSc
 Familial BC 76 (39.6) 159 (48.0)  
 Familial BC and OC 26 (13.6) 25 (7.6)  
Menopausal status
 Premenopausal 174 (91.1) 267 (80.7) 0.002 d
 Postmenopausal 17 (8.9) 64 (19.3)  
 Unknown 1 0  
Ethnicity
 Punjabi 151 (79.5) 229 (69.2) 0.03 e
 Pathan 19 (10.0) 54 (16.3)  
 Others 20 (10.5) 48 (14.5)  
 Unknown 2 0  
Histology
 Ductal 185 (96.4) 294 (89.4) 0.004 f
 Lobular 1 (0.5) 15 (4.6)  
 Mixedg 2 (1.0) 11 (3.3)  
 Mucinous 0 6 (1.8)  
 Metaplastic 2 (1.0) 3 (0.9)  
 Medullary 2 (1.0) 0  
 Unknown 0 2  
Tumor size
 pT1 30 (20.3) 71 (26.9) NSh
 pT2 91 (61.5) 147 (55.7)  
 pT3 24 (16.2) 44 (16.7)  
 pT4 3 (2.0) 2 (0.7)  
 Unknown 44 67  
Tumor grade (Nottingham)
 1 0 5 (1.6) < 0.0001 i
 2 20 (11.2) 111 (35.5)  
 3 158 (88.8) 197 (62.9)  
 Unknown 14 18  
Lymph node status
 Positive 83 (46.1) 212 (67.5) < 0.0001 j
 Negative 97 (53.9) 102 (32.5)  
 Unknown 12 17  
  1. P values marked in bold are statistically significant
  2. BC breast cancer, NS non-significant, OC ovarian cancer, TNBC triple-negative breast cancer. aFisher’s exact test. bWilcoxon rank-sum test. cEarly-onset vs. familial BC and early-onset vs. familial BC and OC. dPremenopausal vs. postmenopausal. ePunjabi vs. Pathan. fDuctal vs. others. gIncluding ductal carcinomas with lobular and mucinous features. hpT1 vs. pT2+. iGrade 1, 2 vs. 3. jLymph node positive vs. negative