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Table 4 Univariate and multivariate analyses of prognostic factors for RFS of patients with resectable thoracic ESCC

From: The pretreatment Controlling Nutritional Status (CONUT) score is an independent prognostic factor in patients with resectable thoracic esophageal squamous cell carcinoma: results from a retrospective study

Variable 5-year RFS (%) Univariate Multivariate
p value HR (95 % CI) p value
Total 57.1    
Age (years)   0.194   
  < 65 63.2    
 ≥65 50.2    
Sex   0.014 0.458 (0.214–0.982) 0.045
 Male 53.1    
 Female 75.1    
BMI   0.394   
 <21.0 62.6    
 ≥21.0 51.4    
PS   <0.001 4.029 (2.041–7.956) <0.001
 0 60.7    
 1/2 8.3    
ASA   0.005   0.010
 1 73.2   1.000  
 2 56.2   1.117 (0.572–2.181) 0.746
 3 10.9   3.600 (1.372–9.443) 0.009
Location   0.803   
 Upper 57.5    
 Middle 58.0    
 Lower 55.0    
cTNM stage   <0.001   0.011
 I 73.1   1.000  
 II 52.5   1.731 (1.006–2.979) 0.048
 III/IV 37.4   2.515 (1.361–4.646) 0.003
SCCA (ng/ml)   0.051 1.226 (0.717–2.097) 0.456
 <2.0 59.0    
 ≥2.0 49.8    
CONUT score   0.003 2.163 (1.139–4.109) 0.018
 High (≥3) 35.3    
 Low (≤2) 59.5    
PLR   0.033 1.129 (0.656–1.943) 0.662
 High (>193) 45.5    
 Low (≤193) 59.5    
NLR   0.030 1.094 (0.569–2.102) 0.788
 High (>3.612) 39.0    
 Low (≤3.612) 59.6    
GPS   0.006 0.955 (0.439–2.078) 0.908
 0 59.8    
 1/2 17.1    
Components of the CONUT score
 Albumin score   0.012 1.334 (0.608–2.928) 0.472
  0 57.7    
  2/4 0    
 TLC score   0.069 1.113 (0.551–2.250) 0.765
  0/1 59.1    
  2/3 42.9    
 TC score   0.050 1.287 (0.604–2.743) 0.513
  0/1 58.4    
  2/3 41.7    
  1. BMI body mass index, PS performance status, ASA American Society of Anesthesiology, TNM tumor-node-metastasis, SCCA squamous cell carcinoma antigen, CONUT Controlling Nutritional Status, PLR platelet to lymphocyte ratio, NLR neutrophil to lymphocyte ratio, GPS Glasgow Prognostic Score, TLC total lymphocyte count, TC total cholesterol
  2. The results of multivariate analyses of sex, PS, ASA, cTNM stage, SCCA in this table are the results of analyses with CONUT score
  3. HRs and p values of PLR, NLR, GPS, Albumin score, TLC score, and TC score in this table are the results of respective multivariate analyses using variables with p < 0.1 on univariate analyses and each factor