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Table 4 Univariate and multivariate analyses of prognostic factors for RFS of patients with resectable thoracic ESCC

From: The pretreatment Controlling Nutritional Status (CONUT) score is an independent prognostic factor in patients with resectable thoracic esophageal squamous cell carcinoma: results from a retrospective study

Variable

5-year RFS (%)

Univariate

Multivariate

p value

HR (95 % CI)

p value

Total

57.1

   

Age (years)

 

0.194

  

  < 65

63.2

   

 ≥65

50.2

   

Sex

 

0.014

0.458 (0.214–0.982)

0.045

 Male

53.1

   

 Female

75.1

   

BMI

 

0.394

  

 <21.0

62.6

   

 ≥21.0

51.4

   

PS

 

<0.001

4.029 (2.041–7.956)

<0.001

 0

60.7

   

 1/2

8.3

   

ASA

 

0.005

 

0.010

 1

73.2

 

1.000

 

 2

56.2

 

1.117 (0.572–2.181)

0.746

 3

10.9

 

3.600 (1.372–9.443)

0.009

Location

 

0.803

  

 Upper

57.5

   

 Middle

58.0

   

 Lower

55.0

   

cTNM stage

 

<0.001

 

0.011

 I

73.1

 

1.000

 

 II

52.5

 

1.731 (1.006–2.979)

0.048

 III/IV

37.4

 

2.515 (1.361–4.646)

0.003

SCCA (ng/ml)

 

0.051

1.226 (0.717–2.097)

0.456

 <2.0

59.0

   

 ≥2.0

49.8

   

CONUT score

 

0.003

2.163 (1.139–4.109)

0.018

 High (≥3)

35.3

   

 Low (≤2)

59.5

   

PLR

 

0.033

1.129 (0.656–1.943)

0.662

 High (>193)

45.5

   

 Low (≤193)

59.5

   

NLR

 

0.030

1.094 (0.569–2.102)

0.788

 High (>3.612)

39.0

   

 Low (≤3.612)

59.6

   

GPS

 

0.006

0.955 (0.439–2.078)

0.908

 0

59.8

   

 1/2

17.1

   

Components of the CONUT score

 Albumin score

 

0.012

1.334 (0.608–2.928)

0.472

  0

57.7

   

  2/4

0

   

 TLC score

 

0.069

1.113 (0.551–2.250)

0.765

  0/1

59.1

   

  2/3

42.9

   

 TC score

 

0.050

1.287 (0.604–2.743)

0.513

  0/1

58.4

   

  2/3

41.7

   
  1. BMI body mass index, PS performance status, ASA American Society of Anesthesiology, TNM tumor-node-metastasis, SCCA squamous cell carcinoma antigen, CONUT Controlling Nutritional Status, PLR platelet to lymphocyte ratio, NLR neutrophil to lymphocyte ratio, GPS Glasgow Prognostic Score, TLC total lymphocyte count, TC total cholesterol
  2. The results of multivariate analyses of sex, PS, ASA, cTNM stage, SCCA in this table are the results of analyses with CONUT score
  3. HRs and p values of PLR, NLR, GPS, Albumin score, TLC score, and TC score in this table are the results of respective multivariate analyses using variables with p < 0.1 on univariate analyses and each factor