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Table 3 Univariate and multivariate analyses of prognostic factors for OS of patients with resectable thoracic ESCC

From: The pretreatment Controlling Nutritional Status (CONUT) score is an independent prognostic factor in patients with resectable thoracic esophageal squamous cell carcinoma: results from a retrospective study

Variable

5-year OS (%)

Univariate

Multivariate

p value

HR (95 % CI)

p value

Total

60.7

   

Age (years)

 

0.089

1.214 (0.753–1.956)

0.427

  < 65

68.5

   

  ≥ 65

52.1

   

Sex

 

0.004

0.276 (0.107–0.711)

0.008

 Male

56.0

   

 Female

83.3

   

BMI

 

0.479

  

 <21.0

67.3

   

 ≥21.0

54.2

   

PS

 

<0.001

4.223 (2.155–8.274)

<0.001

 0

64.6

   

 1/2

8.3

   

ASA

 

<0.001

 

<0.001

 1

81.2

 

1.000

 

 2

59.6

 

1.184 (0.554–2.528)

0.663

 3

10.9

 

5.856 (2.102–16.310)

0.001

Location

 

0.941

  

 Upper

58.6

   

 Middle

60.7

   

 Lower

62.3

   

cTNM stage

 

0.001

 

0.015

 I

75.4

 

1.000

 

 II

57.5

 

1.515 (0.850–2.698)

0.159

 III/IV

40.4

 

2.485 (1.338–4.615)

0.004

SCCA (ng/ml)

 

0.139

  

 <2.0

61.2

   

 ≥2.0

59.6

   

CONUT score

 

<0.001

2.303 (1.191–4.455)

0.013

 High (≥3)

35.3

   

 Low (≤2)

63.6

   

PLR

 

0.025

1.213 (0.696–2.115)

0.496

 High (>193)

52.1

   

 Low (≤193)

62.6

   

NLR

 

0.018

1.194 (0.627–2.273)

0.589

 High (>3.612)

43.5

   

 Low (≤3.612)

63.3

   

GPS

 

0.001

1.021 (0.465–2.245)

0.958

 0

63.9

   

 1/2

16.3

   

Components of the CONUT score

 Albumin score

 

0.012

1.096 (0.479–2.511)

0.828

  0

61.4

   

  2/4

0

   

 TLC score

 

0.074

1.061 (0.518–2.171)

0.872

  0/1

62.6

   

  2/3

47.6

   

 TC score

 

0.015

1.481 (0.688–3.190)

0.316

  0/1

62.4

   

  2/3

40.8

   
  1. BMI body mass index, PS performance status, ASA American Society of Anesthesiology, TNM tumor-node-metastasis, SCCA squamous cell carcinoma antigen, CONUT Controlling Nutritional Status, PLR platelet to lymphocyte ratio, NLR neutrophil to lymphocyte ratio, GPS Glasgow Prognostic Score, TLC total lymphocyte count, TC total cholesterol
  2. The results of multivariate analyses of age, sex, PS, ASA, cTNM stage in this table are the results of analyses with CONUT score
  3. HRs and p values of PLR, NLR, GPS, Albumin score, TLC score, and TC score in this table are the results of respective multivariate analyses using variables with p < 0.1 on univariate analyses and each factor