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Fig. 6 | BMC Cancer

Fig. 6

From: Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity

Fig. 6

a Collagen invasion assay with HT-144 treated with the GC-4 antibody to block N-cadherin. When N-cadherin was blocked with GC-4 the pro-invasive effect of butyrate, TSA and Vorinostat was reverted. b HT-144 cells 48 h after silencing with negative control siRNA and N-cadherin (with and without butyrate) (c) Western Blot analysis of N-cadherin in negative control and N-cadherin siRNA transfected cells. *** Statistically significant difference from control, p < 0.001

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