Fig. 6From: Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity a Collagen invasion assay with HT-144 treated with the GC-4 antibody to block N-cadherin. When N-cadherin was blocked with GC-4 the pro-invasive effect of butyrate, TSA and Vorinostat was reverted. b HT-144 cells 48 h after silencing with negative control siRNA and N-cadherin (with and without butyrate) (c) Western Blot analysis of N-cadherin in negative control and N-cadherin siRNA transfected cells. *** Statistically significant difference from control, p < 0.001Back to article page