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Fig. 3 | BMC Cancer

Fig. 3

From: Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity

Fig. 3

Morphological changes induced by HDACi. a Phalloidin stained HT-144 cells growing in collagen gel after a 24 h treatment with butyrate, TSA, Valproic acid and Vorinostat. b SEM images of A375 invading cells treated with the same agents. All HDACi provoked morphological changes in melanoma cells, which in particular, appeared to be more elongated. c Shape factor, which is around 0.8 in the control, decreases to almost 0.3 with some of the inhibitors. Cells treated with valproic acid did not show a significant decrease in shape factor compared to control. Statistically significant differences from control: ***p < 0.001, ** p < 0.01 and * p < 0.05. Abbreviations: But, butyrate; TSA, Trichostatin A; VPA, valproic acid; Vor, vorinostat

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