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Table 5 Relationship between consumption of non-steroideal anti-inflammatory drugs and breast cancer, according to tumor characteristics

From: Use of non-steroidal anti-inflammatory drugs and risk of breast cancer: The Spanish Multi-Case-control (MCC) study

Variable Category NSAID Unexposed controls/cases (n) Exposed controls/cases (n) OR (95 % CI) P
Clinical stage 1–2 NSAID (all) 1170/696 739/404 0.80 (0.66–0.97 0.02
Aspirin 1807/1047 102/52 0.93 (0.63–1.38) 0.72
Acetic acid derivatives 1753/1025 156/74 0.75 (0.54–1.06) 0.11
Propionic acid derivatives 1350/770 559/329 0.90 (0.74–1.11) 0.33
cox2 inhibitors 1891/1095 18/4 - -
NSAID others 1861/1072 48/27 1.07 (0.61–1.90) 0.81
3–4 NSAID (all) 1170/136 739/68 0.74 (0.51–1.06) 0.10
Aspirin 1807/192 102/12 1.31 (0.66–2.59) 0.44
Acetic acid derivatives 1753/190 156/14 0.99 (0.53–1.83) 0.97
Propionic acid derivatives 1350/147 559/57 0.84 (0.57–1.24) 0.39
cox2 inhibitors 1891/204 18/0 - -
NSAID others 1861/201 48/3 - -
Pathology Ductal cancer NSAID (all) 1170/835 739/454 0.70 (0.58–0.84) <0.001
Aspirin 1807/1225 102/64 0.97 (0.66–1.41) 0.86
Acetic acid derivatives 1753/1204 156/85 0.76 (0.55–1.06) 0.11
Propionic acid derivatives 1350/918 559/371 0.78 (0.64–0.95) 0.01
cox2 inhibitors 1891/1289 18/3 - -
NSAID others 1861/1259 48/30 1.06 (0.60–1.87) 0.85
Non-ductal cancer NSAID (all) 1170/151 739/83 0.82 (0.58–1.15) 0.25
Aspirin 1807/228 102/6 0.50 (0.21–1.19) 0.12
Acetic acid derivatives 1753/219 156/15 0.85 (0.46–1.58) 0.61
Propionic acid derivatives 1350/166 559/68 0.91 (0.63–1.31) 0.60
cox2 inhibitors 1891/234 18/0 - -
NSAID others 1861/232 48/2 - -
Inmunohistochemistry Hormone + NSAID (all) 1170/727 739/390 0.72 (0.60–0.88) <0.001
Aspirin 1807/1069 102/48 0.82 (0.55–1.24) 0.35
Acetic acid derivatives 1753/1044 156/73 0.76 (0.54–1.08) 0.12
Propionic acid derivatives 1350/805 559/312 0.80 (0.65–0.98) 0.03
cox2 inhibitors 1891/1115 18/2 - -
NSAID others 1861/1089 48/28 1.28 (0.73–2.25) 0.38
HER2+ NSAID (all) 1170/739 172/83 0.63 (0.45–0.88) 0.007
Aspirin 1807/102 244/11 0.79 (0.38–1.65) 0.53
Acetic acid derivatives 1753/238 156/17 0.67 (0.36–1.24) 0.20
Propionic acid derivatives 1350/188 559/67 0.66 (0.46–0.95) 0.03
cox2 inhibitors 1891/255 18/0 - -
NSAID others 1861/251 48/4 - -
Triple negative breast cancer NSAID (all) 1170/94 739/63 0.87 (0.58–1.30) 0.49
Aspirin 1807/148 102/9 1.24 (0.57–2.71) 0.59
Acetic acid derivatives 1753/147 156/10 0.86 (0.41–1.79) 0.68
Propionic acid derivatives 1350/103 559/54 0.99 (0.64–1.52) 0.95
cox2 inhibitors 1891/156 18/1 - -
NSAID others 1861/154 48/3 - -
  1. OR Odds ratio adjusted for age, recruitment area, education level, tobacco smoking history, BMI family history of breast cancer, number of deliveries, age at first delivery, menarche age, and menopausal status. CI confidence interval